Recent Advacements on Colon Targeted Drug Delivery Systems

Sirisha

doi:10.5958/2231-5691.2020.00047.7

Asian Journal of Pharmaceutical Research

ISSN

2231-5691 (Online)
2231-5683 (Print)

Submit Article

Recent Advacements on Colon Targeted Drug Delivery Systems

Author(s): Sirisha

Email(s): anjalisiri20@gmail.com

DOI: 10.5958/2231-5691.2020.00047.7

Address: Sirisha*
Sree Venkatsewara University, Tirupathi, Chitoor (Dis).
*Corresponding Author

Published In: Volume - 10, Issue - 4, Year - 2020

View HTML

View PDF

ABSTRACT:
Thus Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system. Thus it highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems are covered with a particular emphasis on formulation technologies.

Keywords:

Cite this article:
Sirisha. Recent Advacements on Colon Targeted Drug Delivery Systems. Asian J. Pharm. Res. 2020; 10(4):268-274. doi: 10.5958/2231-5691.2020.00047.7

Cite(Electronic):
Sirisha. Recent Advacements on Colon Targeted Drug Delivery Systems. Asian J. Pharm. Res. 2020; 10(4):268-274. doi: 10.5958/2231-5691.2020.00047.7 Available on: https://asianjpr.com/AbstractView.aspx?PID=2020-10-4-5

REFERENCES:
1.   Ferlay, J.; Colombet, M.; Soerjomataram, I.; Dyba, T.; Randi, G.; Bettio, M.; Gavin, A.; Visser, O.; Bray, F. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur. J. Cancer 2018, 103, 356–387.
2.   Keum, N.; Giovannucci, E. Global burden of colorectal cancer: Emerging trends, risk factors and prevention bowel disease. Gut 2013, 62, 630–649.
3.   Ng, S.C.; Bernstein, C.N.; Vatn, M.H.; Lakatos, P.L.; Loftus, E.V.; Tysk, C.; O’morain, C.; Moum, B.; Colombel, J.F.; Epidemiology and Natural History Task Force of the International Organization of inflammatory Bowel Disease (IOIBD). Geographical variability and environmental risk factors in inflammatory bowel disease. Gut 2013, 62, 630–649.
4.   Patole, V.C.; Pandit, A.P. Mesalamine-loaded alginate microspheres filled in enteric coated HPMC capsules for local treatment of ulcerative colitis: In Vitro and in vivo characterization. J. Pharm. Investig. 2018, 48, 257–267.
5.   Rahier, J.F.; Magro, F.; Abreu, C.; Armuzzi, A.; Ben-Horin, S.; Chowers, Y.; Cottone, M.; de Ridder, L.; Doherty, G.; Ehehalt, R.; et al. Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J. Crohns. Colitis. 2014, 8, 443–468.
6.   Wang, X.; Yu, D.G.; Li, X.Y.; Bligh, S.W.; Williams, G.R. Electrospun medicated shellac nanofibers for colon-targeted drug delivery. Int. J. Pharm. 2015, 490, 384–390.
7.   Vats, A.; Pathak, K. Exploiting microspheres as a therapeutic proficient doer for colon delivery: A review. Expert Opin. Drug Deliv. 2013, 10, 545–557.
8.   Duran-Lobato, M.; Niu, Z.; Alonso, M.J. Oral delivery of biologics for precision medicine. Adv. Mater. 2019, e1901935. strategies.
9.   Zeeshan, M.; Ali, H.; Khan, S.; Khan, S.A.; Weigmann, B. Advances in orally-delivered pH-sensitive nanocarrier systems; an optimistic approach for the treatment of inflammatory bowel 2019, 558, 201–214.
10.   Ma, X.; Williams, R.O. Polymeric nanomedicines for poorly soluble drugs in oral delivery systems: An update. J. Pharm. Investig. 2018, 48, 61–75.
11.   Mutalik, S.; Suthar, N.A.; Managuli, R.S.; Shetty, P.K.; Avadhani, K.; Kalthur, G.; Kulkarni, R.V.; Thomas, R. Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin. Int. J. Biol. Macromol. 2016, 86, 709–720.
12.   Sahu, K.K.; Pandey, R.S. Development and characterization of HBsAg-loaded Eudragit nanoparticles for effective colonic immunization. Pharm. Dev. Technol. 2019, 24, 166–175.
13.   Naeem, M.; Choi, M.; Cao, J.; Lee, Y.; Ikram, M.; Yoon, S.; Lee, J.; Moon, H.R.; Kim, M.S.; Jung, Y.; et al. Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy. Drug Des. Devel. Ther. 2015, 9, 3789–3799.
14.   Kotla, N.G.; Rana, S.; Sivaraman, G.; Sunnapu, O.; Vemula, P.K.; Pandit, A.; Rochev, Y. Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives. Adv. Drug Deliv. Rev. 2019, 146, 248–266
15.   Morales-Burgos, A.M.; Carvajal-Millan, E.; Rascón-Chu, A.; Martínez-López, A.L.; Lizardi-Mendoza, J.; López-Franco, Y.L.; Brown-Bojorquez, F. Tailoring reversible insulin aggregates loaded in electrosprayed arabinoxylan microspheres intended for colon-targeted delivery. J. Appl. Polym. Sci. 2019, 136, 47960.
16.   16.Miramontes-Corona, C.; Escalante, A.; Delgado, E.; Corona-González, R.I.; Vázquez-Torres, H.; Toriz, G. Hydrophobic agave fructans for sustained drug delivery to the human colon. React. Funct. Polym. 2019, in press.
17.   Zhu, J.; Zhong, L.; Chen, W.; Song, Y.; Qian, Z.; Cao, X.; Huang, Q.; Zhang, B.; Chen, H.; Chen, W. Preparation and characterization of pectin/chitosan beads containing porous starch embedded with doxorubicin hydrochloride: A novel and simple colon targeted drug delivery system. Food Hydrocoll. 2019, 95, 562–570
18.   Barclay, T.G.; Day, C.M.; Petrovsky, N.; Garg, S. Review of polysaccharide particle-based functional drugdelivery. Carbohydr. Polym. 2019, 221, 94–112.
19.   Jain, V.; Shukla, N.; Mahajan, S. Polysaccharides in colon specific drug delivery. J. Transl. Sci. 2015, 1, 3–11.
20.   Wen, Y.; Oh, J.K. Recent strategies to develop polysaccharide-based nanomaterials for biomedical applications. Macromol. Rapid. Commun. 2014, 35, 1819–1832.
21.   Ibekwe, V.C.; Khela, M.K.; Evans, D.F.; Basit, A.W. A new concept in colonic drug targeting: A combined pH-responsive and bacterially-triggered drug delivery technology. Aliment. Pharmacol. Ther. 2008, 28, 911–916.
22.   Ranmal, S.R.; Yadav, V.; Basit, A.W. Targeting the end goal: Opportunities and innovations in colonic drug delivery. ONdrugDelivery Mag. 2017, 77, 22–26.
23.   D’Haens, G.R.; Snadborn, W.J.; Zou, G.; Stitt, L.W.; Rutgeerts, P.J.; Giilgen, D.; Jairath, V.; Hindryckx, P.; Shackelton, L.M.; Vandervoort, M.K.; et al. Randomised non-inferiority trial: 1600 mg versus 400 mg tablets of mesalazine for the treatment of mild-to-moderate ulcerative colitis. Aliment. Pharmacol. Ther. 2017, 46, 292–302.
24.   Dodoo, C.C.; Wang, J.; Basit, A.W.; Stapleton, P.; Gaisford, S. Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation. Int. J. Pharm. 2017, 530, 224–229.
25.   Allegretti, J.R.; Fischer, M.; Sagi, S.V.; Bohm, M.E.; Fadda, H.M.; Ranmal, S.R.; Budree, S.; Basit, A.W.; Glettig, D.L.; de la Serna, E.L.; et al. Fecal microbiota transplantation capsules with targeted colonic versus gastric delivery in recurrent clostridium di_cile infection: A comparative cohort analysis of high and lose dose. Dig. Dis. Sci. 2019, 64, 1672–1678.
26.   Si, X.Y.; Merlin, D.; Xiao, B. Recent advances in orally administered cell-specific nanotherapeutics for inflammatory bowel disease. World J. Gastroenterol. 2016, 22, 7718–7726.
27.   Harel, E.; Rubinstein, A.; Nissan, A.; Khazanov, E.; Nadler Milbauer, M.; Barenholz, Y.; Tirosh, B. Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa. PLoS ONE 2011, 6, e24202.
28.   Xiao, B.; Laroui, H.; Viennois, E.; Ayyadurai, S.; Charania, M.A.; Zhang, Y.; Zhang, Z.; Baker, M.T.; Zhang, B.; Gewirtz, A.T.; et al. Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice. Gastroenterology 2014, 146, 1289–1300.
29.   Yu, M.; Jambhrunkar, S.; Thorn, P.; Chen, J.; Gu, W.; Yu, C. Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanoscale 2013, 5, 178–183.
30.   Liu, K.; Wang, Z.Q.; Wang, S.J.; Liu, P.; Qin, Y.H.; Ma, Y.; Li, X.C.; Huo, Z.J. Hyaluronicacid-tagged silica nanoparticles in colon cancer therapy: Therapeutic efficacy evaluation. Int. J. Nanomed. 2015, 10, 6445–6454.
31.   Vafaei, S.Y.; Esmaeili, M.; Amini, M.; Atyabi, F.; Ostad, S.N.; Dinarvand, R. Self assembled hyaluronic acid nanoparticles as a potential carrier for targeting the inflamed intestinal mucosa. Carbohydr. Polym. 2016, 144, 371–381.
32.   Xiao, B.; Han, M.K.; Viennois, E.; Wang, L.; Zhang, M.; Si, X.; Merlin, D. Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy. Nanoscale 2015, 7, 17745–17755.
33.   Xiao, B.; Zhang, Z.; Viennois, E.; Kang, Y.; Zhang, M.; Han, M.K.; Chen, J.; Merlin, D. Combination therapy for ulcerative colitis: Orally targeted nanoparticles prevent mucosal damage and relieve inflammation. Theranostics 2016, 6, 2250–2266.
34.   Prajapati, S.K.; Jain, A.; Shrivastava, C.; Jain, A.K. Hyaluronic acid conjugated multi-walled carbon nanotubes for colon cancer targeting. Int. J. Biol. Macromol. 2019, 123, 691–703.
35.   Grifantini, R.; Taranta, M.; Gherardini, L.; Naldi, I.; Parri, M.; Grandi, A.; Giannetti, A.; Tombelli, S.; Lucarini, G.; Ricotti, L.; et al. Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer. J. Control. Release 2018, 280, 76–86.
36.   Teruel, A.H.; Pérez-Esteve, É.; González-Álvarez, I.; González-Álvarez, M.; Costero, A.M.; Ferri, D.; Parra, M.; Gaviña, P.; Merino, V.; Martínez-Mañez, R.; et al. Smart gated magnetic silica mesoporous particles for targeted colon drug delivery: New approaches for inflammatory bowel diseases treatment. J. Control. Release 2018, 281, 58–69.
37.   Kono, Y.; Gogatsubo, S.; Ohba, T.; Fujita, T. Enhanced macrophage delivery to the colon using magnetic lipoplexes with a magnetic field. Drug Deliv. 2019, 26, 935–943.
38.   Metwally, A.A.; Hathout, R.M. Computer-assisted drug formulation design: Novel approach in drug delivery. Mol. Pharm. 2015, 12, 2800–2810.
39.   Ramezanpour, M.; Leung, S.S.; Delgado-Magnero, K.H.; Bashe, B.Y.; Thewalt, J.; Tieleman, D.P. Computational and experimental approaches for investigating nanoparticle-based drug delivery systems. Biochim. Biophys. Acta 2016, 1858, 1688–1709.
40.   Vadlapatla, R.; Wong, E.Y.; Gayakwad, S.G. Electronic drug delivery systems: An overview. J. Drug Deliv. Sci. Technol. 2017, 41, 359–366.
41.   Yadav, K.S.; Kapse-Mistry, S.; Peters, G.J.; Mayur, Y.C. E-drug delivery: A futuristic approach. Drug Discov. Today 2019, 24, 1023–1030.

Recomonded Articles:

Pharmaceutical Importance and Significance of Limit Tests

Author(s): Habeeb Ahmed, Mohammed Ehtesham, Nuha Rasheed , Abdul Saleem Mohammad

DOI: 10.5958/2231-5691.2017.00006.5 Access: Open Access Read More

Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects

Author(s): Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank

DOI: Access: Open Access Read More

Sublingual Tablets - An Updated Review

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9 Access: Open Access Read More

A Review on Microsphere and it’s Application

Author(s): Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan

DOI: 10.5958/2231-5691.2019.00020.0 Access: Open Access Read More

Formulation of Povidone Iodine vaginal suppository containing Lacto bacillus spores.

Author(s): S.C. Shivhare, U.D.Shivhare, Preeti Srivastav, K.G. Malviya

DOI: Access: Open Access Read More

The Review on The Nasal Drug Delivery

Author(s): Prajapati M., Mandloi R., Pillai S, Birla N.

DOI: 10.5958/2231-5691.2020.00021.0 Access: Open Access Read More

Review on Solubility Enhancement Techniques

Author(s): B.A. Bhairav, J.K. Bachhav, R.B. Saudagar

DOI: 10.5958/2231-5691.2016.00025.3 Access: Open Access Read More

Analytical Method Development in Pharmaceutical Research: Steps involved in HPLC Method Development

Author(s): Hamid Khan

DOI: 10.5958/2231-5691.2017.00031.4 Access: Open Access Read More

Generic Vs. Brand Medicines: An Overview

Author(s): Nikita R. Nikam, Rohan R. Vakhariya, Dr. C. S. Magdum

DOI: 10.5958/2231-5691.2019.00018.2 Access: Open Access Read More

A Review- Nanosuspension Technology in Drug Delivery System

Author(s): Sarika V. Khandbahale

DOI: 10.5958/2231-5691.2019.00021.2 Access: Open Access Read More

Design, Development and Evaluation of Enteric Coated Tablets of Glimepiride

Author(s): Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum

DOI: 10.5958/2231-5691.2017.00024.7 Access: Open Access Read More

A Review on Natural Binders used in Pharmacy

Author(s): Subhashis Debnath, C. Navya Yadav, N. Nowjiya, M. Prabhavathi, A. SaiKumar, P. Sai Krishna, M. Niranjan Babu

DOI: 10.5958/2231-5691.2019.00009.1 Access: Open Access Read More

Significance of Pharmaceutical Excipients on Solid Dosage form Development: A Brief Review

Author(s): Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap

DOI: 10.5958/2231-5691.2016.00028.9 Access: Open Access Read More

Introduction to Pharmacovigilance and Monitoring

Author(s): Manohar D. Kengar, Kiran K. Patole, Akshay K. Ade, Sumesh M. Kumbhar, Chetan D. Patil, Ashutosh R. Ganjave

DOI: 10.5958/2231-5691.2019.00019.4 Access: Open Access Read More

A Brief Review on Genotoxic impurities in Pharmaceuticals

Author(s): Ashok B. Patel, Ashish H. Asnani, Amitkumar J. Vyas, Nilesh K. Patel, Ajay I. Patel, Arvind N. Lumbhani

DOI: 10.52711/2231-5691.2021.00034 Access: Open Access Read More

A Review on New Herbal Remedies for treatment of Mouth Ulcer

Author(s): Rina G. Maskare, Ayush P. Agrawal, Mayuri S. Pal, Jidnyasa R. Yerne, Megham Chaudhri, Anup R. Bawankar, Gaytri B. Sonkusre

DOI: 10.52711/2231-5691.2022.00025 Access: Open Access Read More

Reverse Logistic Practices on Household Medical Disposal in India and its Impacts on Environment

Author(s): Manoj Kumar. T, Saravanan. S

DOI: 10.5958/2231-5691.2016.00016.2 Access: Open Access Read More

Emulgel: A Review

Author(s): Sahil Hasan, Saloni Bhandari, Anshu Sharma, Poonam Garg

DOI: 10.52711/2231-5691.2021.00047 Access: Open Access Read More

Exploration and Phytochemical Estimation of Murraya koenigii Leaves for Pharmaceutical Applications

Author(s): Radheshyam Sharma, Umesh Kumar

DOI: 10.5958/2231-5691.2019.00025.X Access: Open Access Read More

Development and Validation of UV Spectrophotometric Method for Estimation of Lurasidone in Bulk and Pharmaceutical Formulations

Author(s): K. Vijaya Sri, S. Sravani, M. Shiva Kumar

DOI: 10.5958/2231-5691.2015.00015.5 Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available
DOI: 10.5958/2231–5691