Author(s): Akula Srinivas, Tayyaba Mahtab, Sayeeda Tabasum, Abrar, K. Jyothi

Email(s): akulasrinivas305@gmail.com

DOI: 10.5958/2231-5691.2019.00040.6   

Address: Akula Srinivas1, Tayyaba Mahtab2, Sayeeda Tabasum2, Abrar3, K. Jyothi4
1Department of Pharmacology, St. Mary’s College of Pharmacy, St. Francis Street, Secunderabad, Telangana, India – 500025
2Department of Quality Assurance, Bhaskar Pharmacy College, Yenkapally, Moinabad, Telangana, India – 500075
3Department of Quality Assurance, St. Mary’s College of Pharmacy, St. Francis Street, Secunderabad, Telangana, India – 500025
4Department of Pharmaceutical Chemistry, St. Mary’s College of Pharmacy, St. Francis Street, Secunderabad, Telangana, India – 500025
*Corresponding Author

Published In:   Volume - 9,      Issue - 4,     Year - 2019


ABSTRACT:
A new, simple and selective method was developed to estimate Lenvatinib pharmaceutical dosage form by UPLC. Ideal Chromatographic peak of separation was attained on a Acquity BEH C18 (50*3.0mm. 1.7µm) using mobile phase consisting 0.1% Orthophosphoric acid: ACN (60:40) v/v with detection of 248 nm. Linearity of the drug was observed in the concentration range 60-140 µg /ml (r2 =0.994). From the results, the developed method was simple, sensitive, precise and accurate and it can successfully be applied for the determination of API in the commercial formulations of Lenvatinib in quality control laboratories.


Cite this article:
Akula Srinivas, Tayyaba Mahtab, Sayeeda Tabasum, Abrar, K. Jyothi. Development and Validation of UPLC method for the determination of Lenvatinib in Capsule formulation. Asian J. Pharm. Res. 2019; 9(4):249-252. doi: 10.5958/2231-5691.2019.00040.6


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DOI: 10.5958/2231–5691 


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