Volume No. :   8

Issue No. :  4

Year :  2018

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Calanolide A New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI): A Review

Address:   Mr. Mayur S. Jain*, Dr. Shashikant D. Barhate, Mr. Bhushan P. Gayakwad
Shree Sureshadada Jain Institutes of Pharmaceutical Education and Research, Jammer, Maharashtra (India).
*Corresponding Author
DOI No: 10.5958/2231-5691.2018.00041.2

Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo. Calanolide A is a compound isolated from the latex of the tree, Calophyllum lanigerum (var. austrocoriaceum), that grows in the rain forest of the Malaysian state of Sarawak on the island of Borneo.
Calanolide A, Anti-HIV activity, Reverse transcriptase inhibitor.
Mayur S. Jain, Shashikant D. Barhate, Bhushan P. Gayakwad. Calanolide A New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI): A Review. Asian J. Pharm. Res. 2018; 8(4): 241-242.
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