ABSTRACT:
Objective: This study was intended to investigate the formulation and characterization of Mesalamine or 5-Aminosalicylic acid (5-ASA) pellets using novel excipient and formulated as matrix spheres to controlled the drug release extended period of time. Uniformly distributed throughout the gastrointestinal tract and Avoid dose dumping of drug. Methods: Mesalamine's active pharmaceutical component was characterised, and investigations were conducted prior to formulation to ensure a physical combination of the drug and excipients was achieved. Formulation of mesalamine as matrix pellets by using fluid bed processor and mesalamine loaded into seal coated sugar spheres and extended-release coating with Ethyl cellulose. Ethyl cellulose is pH independent polymer and retarder the drug release throughout the gastrointestinal tract and site-specific action in colon. Hypromellose also act as pore former and drug release based on diffusion mechanism. In drug layering, core pellets contain stearic acid and hydrogenated castor oil internally forming a matrix. Developed mesalamine pellets are characterized such as drug content, invitro drug release and appearances and particle size distribution. Results: Development of Mesalamine pellets based on five strategy From MEZ 1 to MEZ 5 are formulated and Characterization are performed. Based on the invitro drug release studies, we concluded that the formulation MEZ-IV was best formulation. Invitro drug release is consistence throughout 12hours.(1hrs-23%, 2nd hrs 41%, 4hrs-73, 6hrs-86, 8hrs-99% and 12hrs-10.
Cite this article:
Avijeet J. Zalte, Rajendra K. Surawase. Formulation and Characterization of Colon Targeted Mesalamine Pellets. Asian Journal of Pharmaceutical Research. 2024; 14(2):107-3. doi: 10.52711/2231-5691.2024.00018
Cite(Electronic):
Avijeet J. Zalte, Rajendra K. Surawase. Formulation and Characterization of Colon Targeted Mesalamine Pellets. Asian Journal of Pharmaceutical Research. 2024; 14(2):107-3. doi: 10.52711/2231-5691.2024.00018 Available on: https://asianjpr.com/AbstractView.aspx?PID=2024-14-2-3
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