Author(s): Niraj Kale, Ketaki Shinde, Sonam Bendre, Suhit Gilda


DOI: 10.52711/2231-5691.2022.00055   

Address: Niraj Kale*, Ketaki Shinde, Sonam Bendre, Suhit Gilda
GES’s Satara College of Pharmacy, Degaon, Satara (M.S.) India 415004.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2022

Particle engineering is a technique that involves the customization of particles in order to get desired properties of the pharmaceutical products. The use of particle engineering is in obtaining optimum particle size and particle size distribution and getting particles of desired size. The other aspects of the particle engineering involves the morphological changes of the drug substances. The particle engineering involves improvement of physicochemical properties such as solubility, stability, improved bioavailability and formulation of novel drug delivery systems such as pulmonary drug delivery system. This article includes various techniques used for the particle engineering such as Micronization, Spray drying, high pressure homogenization, Supercritical fluid technology and freeze drying. Article also covers the different uses of particle engineering in pharmaceutical industry.

Cite this article:
Niraj Kale, Ketaki Shinde, Sonam Bendre, Suhit Gilda. Particle Engineering for Customized Drug Particles and its Applications. Asian Journal of Pharmaceutical Research 2022; 12(4):349-8. doi: 10.52711/2231-5691.2022.00055

Niraj Kale, Ketaki Shinde, Sonam Bendre, Suhit Gilda. Particle Engineering for Customized Drug Particles and its Applications. Asian Journal of Pharmaceutical Research 2022; 12(4):349-8. doi: 10.52711/2231-5691.2022.00055   Available on:

1.    Tanhaei, M. Mohammadi, H. Hamishehkar, et al., Electrospraying as a novel method of particle engineering for drug delivery vehicles, Journal of Controlled Release (2020),
2.    Vandana KR, Raju YP, Chowdary VH, Sushma M, Kumar NV. An overview on in situ micronization technique–An emerging novel concept in advanced drug delivery. Saudi Pharmaceutical Journal. 2014 Sep 1;22(4):283-9.
3.    Blagden N, de Matas M, Gavan PT, York P. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Advanced Drug Delivery Reviews. 2007 Jul 30;59(7):617-30.
4.    Sathisaran I, Dalvi SV. Engineering cocrystals of poorly water-soluble drugs to enhance dissolution in aqueous medium. Pharmaceutics. 2018 Sep;10(3):108.
5.    Kim S, Wei C, Kiang S. Crystallization process development of an active pharmaceutical ingredient and particle engineering via the use of ultrasonics and temperature cycling. Organic Process Research & Development. 2003 Nov 21;7(6):997-1001.
6.    Edueng K, Mahlin D, Larsson P, Bergström CA. Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways. Journal of Controlled Release. 2017 Jun 28;256:193-202.
7.    Laitinen R, Löbmann K, Strachan CJ, Grohganz H, Rades T. Emerging trends in the stabilization of amorphous drugs. International Journal of Pharmaceutics. 2013 Aug 30;453(1):65-79.
8.    Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H, Cho JM, Yun G, Lee J. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian Journal of Pharmaceutical Sciences. 2014 Dec 1;9(6):304-16.
9.    Midoux N, Hošek P, Pailleres L, Authelin JR. Micronization of pharmaceutical substances in a spiral jet mill. Powder Technology. 1999 Sep 1;104(2):113-20.
10.    Pasquali I, Bettini R, Giordano F. Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics. European Journal of Pharmaceutical Sciences. 2006 Mar 1;27(4):299-310.
11.    Albert H. L. Chow,1,4 Henry H. Y. Tong,2 Pratibhash Chattopadhyay,3 and Boris Y. Shekunov3, Particle Engineering for Pulmonary Drug Delivery, Pharmaceutical Research, Vol. 24, No. 3, March 2007 (# 2007) DOI: 10.1007/s11095-006-9174-3
12.    Shoyele SA, Cawthorne S. Particle engineering techniques for inhaled biopharmaceuticals. Advanced Drug Delivery Reviews. 2006 Oct 31;58(9-10):1009-29.
13.    Giry K, Péan JM, Giraud L, Marsas S, Rolland H, Wüthrich P. Drug/lactose co-micronization by jet milling to improve aerosolization properties of a powder for inhalation. International Journal of Pharmaceutics. 2006 Sep 14;321(1-2):162-6.
14.    Kougoulos E, Smales I, Verrier HM. Towards integrated drug substance and drug product design for an active pharmaceutical ingredient using particle engineering. AAPS Pharmscitech. 2011 Mar;12(1):287-94.
15.    El-Gendy N, Bailey MM, Berkland C. Particle engineering technologies for pulmonary drug delivery. InControlled pulmonary drug delivery 2011 (pp. 283-312). Springer, New York, NY.
16.    Herpin MJ, Smyth HD. Super-heated aqueous particle engineering (SHAPE): A novel method for the micronization of poorly water soluble drugs. Journal of Pharmaceutical Investigation. 2018 Jan;48(1):135-42.
17.    Moura C, Neves F, Costa E. Impact of jet-milling and wet-polishing size reduction technologies on inhalation API particle properties. Powder Technology. 2016 Sep 1;298:90-8.
18.    Brunaugh A, Smyth HD. Process optimization and particle engineering of micronized drug powders via milling. Drug Delivery and Translational Research. 2018 Dec 15;8(6):1740-50.
19.    Fukunaka T, Sawaguchi K, Golman B, Shinohara K. Effect of particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling on cohesiveness. Journal of Pharmaceutical Sciences. 2005 May 1;94(5):1004-12.
20.    Silva AS, Tavares MT, Aguiar-Ricardo A. Sustainable strategies for nano-in-micro particle engineering for pulmonary delivery. Journal of Nanoparticle Research. 2014 Nov;16(11):1-7.
21.    Vehring R. Pharmaceutical particle engineering via spray drying. Pharmaceutical Research. 2008 May;25(5):999-1022.
22.    Kaialy W, Nokhodchi A. Particle engineering for improved pulmonary drug delivery through dry powder inhalers. Pulmonary drug delivery: advances and challenges. Eds. Nokhodchi, A., Martin, GP. 2015 May 29:171-98.
23.    Kumar RS, Sai TM. Particle Engineering Techniques: A Boon in Enhancing Dissolution Rate of Poorly Water Soluble Drugs. Journal of Drug Delivery and Therapeutics. 2019 Dec 18;9(4-A):897-900.
24.    Hu J. A nanoparticle engineering process: Spray-freezing into liquid to enhance the dissolution of poorly water soluble drugs. The University of Texas at Austin; 2003.
25.    Rogers TL, Nelsen AC, Sarkari M, Young TJ, Johnston KP, Williams RO. Enhanced aqueous dissolution of a poorly water soluble drug by novel particle engineering technology: Spray-freezing into liquid with atmospheric freeze-drying. Pharmaceutical Research. 2003 Mar; 20(3): 485-93.
26.    Patel RP, Patel MP, Suthar AM. Spray drying technology: an overview. Indian Journal of Science and Technology. 2009 Oct 1;2(10):44-7.
27.    Arpagaus C. Pharmaceutical particle engineering via nano spray drying—process parameters and application examples on the laboratory-scale. Int. J. Med. Nano Res. 2018;5(1):026.
28.    Khandouzi F, Daman Z, Gilani K. Optimized particle engineering of fluticasone propionate and salmeterol xinafoate by spray drying technique for dry powder inhalation. Advanced Powder Technology. 2017 Feb 1;28(2):534-42.
29.    Deelip Derle*1, Jatin Patel1, Devendra Yeole1, Amit Patel1, Ashok Pingle1, Particle Engineering Techniques To Enhance Dissolution Of Poorly Water Soluble Drugs, International Journal Of Current Pharmaceutical Research Vol 2, Issue 1, 2010
30.    Sapra M, Ugrani S, Mayya YS, Venkataraman C. Estimation of critical supersaturation solubility ratio for predicting diameters of dry particles prepared by air-jet atomization of solutions. Journal of Colloid and Interface Science. 2017 Aug 15;500:172-81.
31.    Bohr A, P Boetker J, Rades T, Rantanen J, Yang M. Application of spray-drying and electrospraying/electospinning for poorly watersoluble drugs: A particle engineering approach. Current Pharmaceutical Design. 2014 Jan 1;20(3):325-48.
32.    Patel B, Gupta N, Ahsan F. Particle engineering to enhance or lessen particle uptake by alveolar macrophages and to influence the therapeutic outcome. European Journal of Pharmaceutics and Biopharmaceutics. 2015 Jan 1;89:163-74.
33.    Shoyele SA, Sivadas N, Cryan SA. The effects of excipients and particle engineering on the biophysical stability and aerosol performance of parathyroid hormone (1-34) prepared as a dry powder for inhalation. AAPS Pharmscitech. 2011 Mar;12(1):304-11.
34.    Lorraine M. Nolan, Jianhe Li, Lidia Tajber, Owen I. Corrigan, Anne Marie Healy∗,Particle engineering of materials for oral inhalation by dry powder inhalers. II—Sodium cromoglicate, International Journal of Pharmaceutics 405 (2011) 36–46 doi:10.1016/j.ijpharm.2010.11.040
35.    Björnmalm M, Yan Y, Caruso F. Engineering and evaluating drug delivery particles in microfluidic devices. Journal of Controlled Release. 2014 Sep 28;190:139-49.
36.    Sahoo A, Suryanarayanan R, Siegel RA. Stabilization of Amorphous Drugs by Polymers: The Role of Overlap Concentration (C*). Molecular Pharmaceutics. 2020 Sep 25;17(11):4401-6.
37.    Klara Haas, Thomas Dohnal, Patricia Andreu, Egon Zehetner, Anke Kiesslich, Marcus Volkert, Peter Fryer, Henry Jaeger, Particle engineering for improved stability and handling properties of carrot concentrate powders using fluidized bed granulation and agglomeration, Powder Technology 370 (2020) 104–115
38.    Chattoraj S, Sun CC. Crystal and particle engineering strategies for improving powder compression and flow properties to enable continuous tablet manufacturing by direct compression. Journal of Pharmaceutical Sciences. 2018 Apr 1;107(4):968-74.
39.    R Williams D. Particle engineering in pharmaceutical solids processing: surface energy considerations. Current Pharmaceutical Design. 2015 Jun 1;21(19):2677-94.
40.    Marwaha M, Sandhu D, Marwaha RK. Coprocessing of excipients: a review on excipient development for improved tabletting performance. International Journal of Applied Pharmaceutics. 2010 Apr;2(3):41-7.
41.    Perumalla SR, Sun CC. Enabling tablet product development of 5-fluorocytosine through integrated crystal and particle engineering. Journal of Pharmaceutical Sciences. 2014 Apr 1;103(4):1126-32.
42.    Solomon S, Ziaee A, Giraudeau L, O'Reilly E, Walker G, Albadarin AB. Particle engineering of excipients: A mechanistic investigation into the compaction properties of lignin and [co]-spray dried lignin. International Journal of Pharmaceutics. 2019 May 30;563:237-48.
43.    Martyn David Ticehursta And Ivan Marzianob, Integration Of Active Pharmaceutical Ingredient Solid Form Selection And Particle Engineering Into Drug Product Design. Journal Of Pharmacy And Pharmacology, Doi: 10.1111/Jphp.12375 (2014)
44.    He X, Griesser UJ, Stowell JG, Borchardt TB, Byrn SR. Conformational color polymorphism and control of crystallization of 5‐methyl‐2‐[(4‐methyl‐2‐nitrophenyl) amino]‐3‐thiophenecarbonitrile. Journal of Pharmaceutical Sciences. 2001 Mar;90(3):371-88.
45.    Nogueira BA, Castiglioni C, Fausto R. Color polymorphism in organic crystals. Communications Chemistry. 2020 Mar 17;3(1):1-2.
46.    Sharma Deepak, Kumar Dinesh, Singh Mankaran, Singh Gurmeet, Rathore Mahendra Singh, Taste Masking Technologies: A Novel Approach For The Improvement Of Organoleptic Property Of Pharmaceutical Active Substance, In International Research Journal Of Pharmacy. April 2012
47.    Dhakate CS, Upadhye KP, Dixit GR, Bakhale SS, Umate RM. Taste masking by co-crystallization: A review. World J Pharm Res. 2017 May 18.
48.    Savjani JK. Co‐crystallization: An approach to improve the performance characteristics of active pharmaceutical ingredients. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm. 2015 Jul 15;9(3):147-51.
49.    Wadhwa J, Puri S. Taste masking: A novel approach for bitter and obnoxious drugs. International Journal of Biopharmaceutical & Toxicological Research. 2011;1(1):47-60.
50.    Madene A, Jacquot M, Scher J, Desobry S. Flavour encapsulation and controlled release–a review. International Journal of Food Science & Technology. 2006 Jan;41(1):1-21.
51.    Suphla Gupta, Saima Khan, Malik Muzafar, Manoj Kushwaha, Arvind Kumar Yadav, Ajai Prakash Gupta, Encapsulation: Entrapping Essential Oil/Flavors/ Aromas In Food, Encapsulations. Http://Dx.Doi.Org/10.1016/B978-0-12-804307-3.00006-5
52.    Abdou EM. Sweet co-crystals for pediatric drugs formulation. Acta Scientific Pharmaceutical Sciences. 2018;2:01.
53.    Antonio Tabernero, Eva M. Martín del Valle∗, Miguel A. Galán, Supercritical fluids for pharmaceutical particle engineering: Methods, basic fundamentals and modelling, Chemical Engineering and Processing 60 (2012) 9– 25
54.    Dennehy RD. Particle engineering using power ultrasound1. Organic Process Research & Development. 2003 Nov 21;7(6):1002-6.
55.    Kougoulos E, Marziano I, Miller PR. Lactose particle engineering: Influence of ultrasound and anti-solvent on crystal habit and particle size. Journal of Crystal Growth. 2010 Nov 15;312(23):3509-20.
56.    Rojas PE, Sala S, Elizondo E, Veciana J, Ventosa N. Particle engineering with CO 2-Expanded Solvents: The DELOS platform. InAdvances in Organic Crystal Chemistry 2015 (pp. 73-93). Springer, Tokyo.
57.    Sowa M, Klapwijk AR, Ostendorf M, Beckmann W. Particle engineering of an active pharmaceutical ingredient for improved micromeritic properties. Chemical Engineering & Technology. 2017 Jul;40(7):1282-92.
58.    Vinjamuri BP, Haware RV, Stagner WC. Inhalable ipratropium bromide particle engineering with multicriteria optimization. Aaps Pharmscitech. 2017 Aug;18(6):1925-35.
59.    Stefan Bötschi, Ashwin Kumar Rajagopalan, Igor Rombaut Manfred Morari, Marco Mazzotti. From needle-like toward equant particles: A controlled crystal shape engineering pathway, Computers and Chemical Engineering 131 (2019) 106581
60.    Yang Y, Nie D, Liu Y, Yu M, Gan Y. Advances in particle shape engineering for improved drug delivery. Drug Discovery Today. 2019 Feb 1;24(2):575-83.
61.    Pallai-Varsányi E, Tóth J, Gyenis J. Drying of suspensions and solutions on inert particle surface in mechanically spouted bed dryer. China Particuology. 2007 Oct 1;5(5):337-44.
62.    Majerik V, Horváth G, Charbit G, Badens E, Szokonya L, Bosc N, Teillaud E. Novel particle engineering techniques in drug delivery: Review of coformulations using supercritical fluids and liquefied gases. Hungarian Journal of Industry and Chemistry. 2004 Sep 1;32(1).
63.    Pawar N, Saha A, Nandan N, Parambil JV. Solution cocrystallization: A scalable approach for cocrystal production. Crystals. 2021 Mar;11(3):303.
64.    Ronald G. Iacocca, Christopher L. Burcham, Lori R. Hilden, Particle Engineering: A Strategy For Establishing Drug Substance Physical Property Specifications During Small Molecule Development, Journal Of Pharmaceutical Sciences, Vol. 99, No. 1, January 2010
65.    Joshi R, Raje S, Akram W, Garud N. Particle engineering of fenofibrate for advanced drug delivery system. Future Journal of Pharmaceutical Sciences. 2019 Dec;5(1):1-1.
66.    Li Z, Lin X, Shen L, Hong Y, Feng Y. Composite particles based on particle engineering for direct compaction. International Journal of Pharmaceutics. 2017 Mar 15;519(1-2):272-86.
67.    Lobo JM, Schiavone H, Palakodaty S, York P, Clark A, Tzannis ST. SCF-engineered powders for delivery of budesonide from passive DPI devices. Journal of Pharmaceutical Sciences. 2005 Oct 1;94(10):2276-88.
68.    Majerik V, Horváth G, Charbit G, Badens E, Szokonya L, Bosc N, Teillaud E. Novel particle engineering techniques in drug delivery: Review of coformulations using supercritical fluids and liquefied gases. Hungarian Journal of Industry and Chemistry. 2004 Sep 1;32(1).
69.    Wan F, Maltesen MJ, Bjerregaard S, Foged C, Rantanen J, Yang M. Particle engineering technologies for improving the delivery of peptide and protein drugs. Journal of Drug Delivery Science and Technology. 2013 Jan 1;23(4):355-63.
70.    Ógáin ON, Li J, Tajber L, Corrigan OI, Healy AM. Particle engineering of materials for oral inhalation by dry powder inhalers. I—Particles of sugar excipients (trehalose and raffinose) for protein delivery. International Journal of Pharmaceutics. 2011 Feb 28;405(1-2):23-35.
71.    Rathod S, Mali S, Shinde N, Aloorkar N. Cosmeceuticals and Beauty Care Products: Current trends with future prospects. Research Journal of Topical and Cosmetic Sciences. 2020;11(1):45-51.
72.    Kale N, Rathod S, More S, Shinde N. Phyto-Pharmacological Profile of Wrightia tinctoria. Asian Journal of Research in Pharmaceutical Sciences. 2021 Nov 26;11(4):301-8.
73.    Sanket Rathod, Ketaki Shinde, Namdeo Shinde, Nagesh Aloorkar. Cosmeceuticals and Nanotechnology in Beauty Care Products. Research Journal of Topical and Cosmetic Sciences. 2021; 12(2):93-1.
74.    B.A. Bhairav, J.K. Bachhav, R.B. Saudagar. Review on Solubility Enhancement Techniques. Asian J. Pharm. Res. 2016; 6(3): 147-152.
75.    Rutuja S. Shah, Rutuja R. Shah, Manoj M. Nitalikar, Chandrakant S. Magdum. Microspheres by Spray Drying: An Approach to Enhance Solubility of Bicalutamide. Asian J. Pharm. Res. 2017; 7(3): 183-188.

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