A new simple spectrophotometric method was developed for the determination of binary mixtures of Candesartan cilexetil (CAND) and Hydrochalorothiazide (HCTZ), without prior separation. The method is based on the multi-wavelength technique i.e. classical least square (CLS) method. The tablet is determined by the multi-wavelength technique (CLS), at the wavelengths range of 215-225 nm over the concentration ranges of 2.5–50 and 1–30 µg/mL with mean recovery more than 98% for both drugs CAND and HCTZ, respectively .The proposed spectrophotometric method was validated and successfully applied for the assay of drug combination in several laboratory-prepared mixtures and commercial tablets.
Cite this article:
S. J. Daharwal, Veena D. Singh. Development of classical least square method for the determination of Candesartan and Hydrochlorthiazide in tablet dosage form. Asian J. Pharm. Res. 5(2): April-June 2015; Page 90-95. doi: 10.5958/2231-5691.2015.00013.1