Author(s): M. Sunitha Reddy, Baskarla Sravani

Email(s): baddam_sunitha@jntuh.ac.in

DOI: 10.52711/2231-5691.2021.00040   

Address: Dr. M. Sunitha Reddy*, Baskarla Sravani
Associate Professor, Centre for Pharmaceutical Sciences, Department of Pharmaceutics, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Telangana.
*Corresponding Author

Published In:   Volume - 11,      Issue - 4,     Year - 2021


ABSTRACT:
Present research work was aimed to enhance aqueous solubility and dissolution rate of olanzapine by solid self nano emulsifying drug delivery system(S-SNEDDS). Olanzapine is a BCS class II drug having 65% oral bioavailability; it is used in the treatment of psychosis, depression and mania conditions. Oils, Surfactants, Co surfactants were selected depending upon the saturated solubility of olanzapine in those components; excipients were screened depending on olanzapine solubility in various oils, surfactants and co surfactants. Surfactant: co surfactant {Smix} ratios i.e., 3:1 and 4:1 were prepared to determine nano emulsion regions and also to formulate liquid self nano emulsifying drug delivery system (L-SNEDDS). Pseudo ternary phase diagram were plotted by using Triplot version 4.1.2 software, nano emulsion region was determined and evaluated. Formulations were designed based on saturated solubility of olanzapine and Pseudo ternary phase diagram using various ratios of oils [Capryol 90], surfactants [Kolliphor EL], co surfactants [Lauroglycol 90] depending on its solubility and nano emulsion formation four formulations were developed which are further selected for characterisation of L-SNEDDS like robustness to dilution, self emulsification, determination of droplet size, PDI, Drug loading efficacy, zeta potential and also Invitro drug release. Among those four formulations, F1 (SB184J 4:6) was optimum because compared to other three formulations F3 gave best results in terms of droplet size (66nm) with PDI (0.24), Invitro drug release, dissolution rate of F1 SNEDDS having (88.201± 0.25%). Invitro drug release of F1 formulation was compared with that of Olanzapine [API] (45.281± 0.52%) the results indicating that there is a increase in solubility and dissolution rate of olanzapine by 2.2 times more compared to pure olanzapine (API). F1 (SB184J 4:6) were converted into S-SNEDDS by adsorption process by addition porous carriers (Aerosil 200). Formulated S-SNEDDS were undergone various evaluation parameters and also reconstitution parameters to determine Droplet size and Invitro drug release of solid F1 (SB184J4:6) formulation. The results of present study demonstrates that olanzapine SNEDDS has an ability and potential to enhance solubility and dissolution rate.


Cite this article:
M. Sunitha Reddy, Baskarla Sravani. Formulation and Evaluation of Solid Self Nano Emulsifying drug delivery System of Olanzapine to Enhance Aqueous Solubility and Dissolution Rate. Asian Journal of Pharmaceutical Research. 2021; 11(4):227-8. doi: 10.52711/2231-5691.2021.00040

Cite(Electronic):
M. Sunitha Reddy, Baskarla Sravani. Formulation and Evaluation of Solid Self Nano Emulsifying drug delivery System of Olanzapine to Enhance Aqueous Solubility and Dissolution Rate. Asian Journal of Pharmaceutical Research. 2021; 11(4):227-8. doi: 10.52711/2231-5691.2021.00040   Available on: https://asianjpr.com/AbstractView.aspx?PID=2021-11-4-2


REFERENCES:
1.    Koushik Yetukuri and Preethi sudheer, Approaches to development of solid self micron emulsifying drug delivery system; formulation techniques, International journal of pharmaceutical sciences and drug research 2012, vol 3(10) 3550-58 http://dx.doi.org/10.13040/IJPSR.0975-8232.
2.    Amit Chaudhary, Upendra Nagaich, Neha Gulati, V.K. Sharma, R.L. Khosa, Enhancement of Solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education and Research 2012, vol 2(1),32 – 67.
3.    Heba A. Aboutaleb, Rasha M. Kharshoum, Hatem R. Ismail, Formulation and optimisation of solid self nano emulsifying drug delivery system using porous carriers, International journal of pharmacy and pharmaceutical sciences 2016, vol 8(1),433-438.
4.    Sangamita N.Skula, Dr. Dikshit C.Modi, Dr. Dhiren P.Shah, A review on solid self nano emulsifying drug delivery system an approach on enhanced bioavailability, World journal of pharmacy and pharmaceutical sciences, 2016, vol 5(5),302-316.
5.    Abhijit A Date, Neha Desai, Rahul Dixit, Mangal Nagarsenkar, Self nano emulsifying drug delivery delivery sytems, formulation insights applications, Nano medicine 2010, vol 5(10).
6.    Rakanth S, Ashok kumar, Thiruvengadarajan VS, Gopinath C, Preparation and Characterisation of self emulsifying drug delivery system of carvediol, International journal of current pharmaceutical research, 2016, vol 8(1), 40-45.
7.    Febi S Kuruvila, Flowerlet Mathew, S. Kuppuswamy, Solid self nano emulsifying drug delivery system development and future aspects, Asian journal of pharmaceutical research 2013, vol 3(1),20-26.
8.    Dr. Shaukat Ali, Dr. Karl Kolter, Challenges and opportunities in oral formulations and development, Asian journal of pharmaceutical and clinical research 2019, vol 12(1), 551.
9.    V.Rajeshwar and Birendra shrivastava, Self emulsifying drug delivery system a conventional and alternative approach to improve oral bioavailability, International journal of pharmaceutical sciences and research, 2018, vol 9(8), 3114-3127
10.    Madhavi K, Shikha A, Suresh B Formulation and Invitro characterisation of solid self nano emulsifying drug delivery system of Ramipril prepared by Adsorption method, International journal of cureent pharmaceutical research, 2016, vol 8(1), 40-45.
11.    Anjan kumar, Ranjith Prasad, Murthy Self emulsifying drug delivery system (SEDDS) an update from formulation development to therapeutic strategies, International journal of pharmatech research 2014, vol 6(2), 546-568.
12.    Rajendra Narayan Dash, Touseef Humara, Mohammed Habibbudin, Design optimisation and evaluation of glipizide solid self nano emulsifying drug delivery system for enhanced solubility, Saudi pharmaceutical journal, 2015, vol 23(5), 528-540.
13.    Nikhil k Sachan, A Bhattacharya, Seema Pushka, A Mishra, Biopharmaceutical classification system: A strategic tool for oral drug delivery technology: Asian journal of pharmaceutics, 2009, vol 3, 76-81.
14.    Raman kumar Puppala, Vijaya lakshmi, Optimisation and solubilisation of nano emulsion budesonide and constructing phase diagram, Asian journal of pharmaceutical and clinical research, 2019, vol 12(1), 551-553.
15.    Rajendra Narayan Dash, Touseef Humara, Mohammed Habibbudin, Design optimisation and evaluation of glipizide solid self nano emulsifying drug delivery system for enhanced solubility, Saudi pharmaceutical journal, 2015, vol 23(5), 528-540.
16.    Baddam Sunitha Reddy, G.Harrish, Fazal UL-HAQ, Formulation and development of solid self nano emulsifying drug delivery system of rivilpirin, International journal of pharmaceutical sciences and research 2016, vol 7(7), 3117-3129
17.    M.Suntha Reddy, P. Srinivas Goud, S.S. Apte, Solubility enhancement of candesartan cilexetil by self emulsifying drug delivery system, International journal of pharmaceutical sciences and research 2012, vol 3(7), 2098-2140.
18.    A. Abdul Whhab Shahba, A.Riaz Ahmed, K.Mohsin. F.Kaed Alanazi, Solidification of cinnarzine self nano emulsifying drug delivery system by fluid bed coating, National library of medicine 2017, vol 72(3), 143-151
19.    Rajendra narayan dash, Mohammad Habibuddin, Tousef Humaria, Devi ramesh, Design optimisation of glipizide solid self nano emulsifying drug delivery system for enhanced s634b535ty (2015), Saudi pharmaceutical journal, 2009, pg 524-540
20.    M.Suntha Reddy, B.Sravanthi, Formulation and Invitro characterisation of solid self nano emulsifying drug delivery system of atorvastatin calcium, Asian journal of pharmaceutics 2017, vol 11(4), 991-999.
21.    Patel Teja B, Patel Tushar, Suhagia BN9, Preparation and characterisation of micro emulsion for topical use of Itraconazole, Journal of drug delivery and therapeutics, 2018, vol 8(2), 136-145.
22.    Sagar K. Savale, A review on self nano emulsifying drug delivery system, International journal of research in pharmaceuticals and nano sciences, 2015, vol 4(6), 385-397.
23.    Jagadeesh Kumar Arun, Rajeshwar V, Birendra Shrivastava, Vasudha Bakshi, Self nano emulsifying drug delivery system anovel technologies for enhancement of oral bioavailability, Research journal of pharmaceutics 2019, vol 15(5), 2516-2521
24.    Naser M, Y Hasen, Mohammad A Khaleef, Adbullah S Altwairqi, Abdulmahjeed G. Alqurashi, Effect of self micro emulsifying lipid formulation on the dissolution and comparison profiles of Tablets containing theophylline, Journal of applied pharmaceutical sciences, 2018, vol 8(6), 30-38
25.    Gowthami Kuruba, Kavitha Arenur Narayana Reddy, Samatha Poli, Chandramouli Ramnarayanan, Quality design based development of self nano emulsifying drug delivery system of Ritonovir, Journal of young pharmacists 2020, vol 12(3), 215-220
26.    Feng N, Zhang P, Liu Y, Xu J, Preparation and evaluation of self micro emulsifying drug delivery system of oridonin. Int J Pharm, 2007, 9(3), 269-76.
27.    Dr.M.Sunitha Reddy, N.Sowjanya, Formulation and Invitro characterisation of solid self nano emulsifying drug delivery system (s-SNEDDS) of simvastatin. Journal of pharmaceutical sciences and research 2015, vol 7(1) 40-48.
28.    Abdul Bari Mohd, Krishna Sanka, Srikanth Bandi, Prakash V. Diwan & Nalini Shastri, Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and anti diabetic activity in albino rabbits International journal of drug delivery 2014, vol 22(4), 499-508
29.    Preeti K Suresh; Sudhanshu Sharma, Formulation and Invitro characterization of self-nano emulsifying drug delivery system of Cinnarzine. Pharmacie Globale (IJCP), 2015, vol 9(08),1 -6
30.    Reddy MS, Rambabu B, Vijetha KA, Development and evaluation of solid self nano emulsifying drug delivery system of poorly soluble Olmesartan medoxomil by using adsorption on to solid carrier technique. International Journal of Pharmaceutics Sci, 2018 vol 9, 3398-3407.

Recomonded Articles:

Author(s): Habeeb Ahmed, Mohammed Ehtesham, Nuha Rasheed , Abdul Saleem Mohammad

DOI: 10.5958/2231-5691.2017.00006.5         Access: Open Access Read More

Author(s): C. Muralikrishna Goud, Syeda Mariya Ghazanfar

DOI: 10.52711/2231-5691.2021.00025         Access: Open Access Read More

Author(s): R. R. Shah, S. A. Mohite, N. R. Patel

DOI: 10.5958/2231-5691.2018.00007.2         Access: Open Access Read More

Author(s): Jaya Preethi P, Padmini K, Srikanth J, Lohita M, Swetha K

DOI:         Access: Open Access Read More

Author(s): Ravi Kumar, Komal

DOI: 10.5958/2231-5691.2021.00003.4         Access: Open Access Read More

Author(s): Bhushan P. Gayakwad, Shashikant D. Barhate, Mayur S. Jain

DOI: 10.5958/2231-5691.2017.00038.7         Access: Open Access Read More

Author(s): Manohar D. Kengar, Asha M. Jagtap, Akshata S. Gavade, Ganesh B. Vambhurkar, Mangesh A. Bhutkar

DOI: 10.5958/2231-5691.2018.00045.X         Access: Open Access Read More

Author(s): D. Sunitha, K. Hemalatha, M. Sudhakar

DOI: 10.5958/2231-5691.2016.00029.0         Access: Open Access Read More

Author(s): AK Meena, MM Rao, RP Meena, P Panda, Renu

DOI:         Access: Open Access Read More

Author(s): Hiral A. Makadia, Ami Y. Bhatt, Ramesh B. Parmar, Ms. Jalpa S. Paun, H.M. Tank

DOI:         Access: Open Access Read More

Author(s): Ashok Thulluru, Nawaz Mahammed, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana

DOI: 10.5958/2231-5691.2019.00016.9         Access: Open Access Read More

Author(s): Sonali Syal, Vinay Pandit, M. S Ashawat

DOI: 10.5958/2231-5691.2020.00034.9         Access: Open Access Read More

Author(s): Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan

DOI: 10.5958/2231-5691.2019.00020.0         Access: Open Access Read More

Author(s): Mohammad Shamim Qureshi, A. Venkateshwar Reddy, G. S. Kumar, Lubna Nousheen

DOI: 10.5958/2231-5691.2017.00017.X         Access: Open Access Read More

Author(s): Pranit P. Gayakar, Rahul S. Adnaik, Amit D. Jadhav, Shrinivas K. Mohite

DOI:         Access: Open Access Read More

Author(s): Mr. Paresh A Patil, Mr. Vitthal. V. Bhosale, Ms. Varsha. P. Girase

DOI: 10.5958/2231-5691.2020.00023.4         Access: Open Access Read More

Author(s): Mohite M S, Shelar P A, Raje V N., Babar S. J., Sapkal R. K.

DOI:         Access: Open Access Read More

Author(s): S.C. Shivhare, U.D.Shivhare, Preeti Srivastav, K.G. Malviya

DOI:         Access: Open Access Read More

Author(s): Prajapati M., Mandloi R., Pillai S, Birla N.

DOI: 10.5958/2231-5691.2020.00021.0         Access: Open Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags