Author(s): Murugesan Amudha, Shanmugam Rani

Email(s): amudhapharma3@gmail.com

DOI: 10.5958/2231-5691.2020.00030.1   

Address: Murugesan Amudha1*, Shanmugam Rani2
1Associate Professor, Pannai College of Pharmacy, Dindigul- 624005.
2 Associate Professor, Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar- 608002, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2020


ABSTRACT:
Infertility, although not life threatening, initiates extreme mental distress and disturbances that can be best portrayed by infertile couples only. World Health Organization revealed that approximately 80% of the world’s population currently uses medicines from herbal origin in healing different ailments due to their availability affordability and accessibility. The parts of plant Cordia retusa are used for female reproductive disorders. Hence the present work was executed to evaluate the fertility intensifying effect of aerial parts of Cordia retusa which is traditionally used as a fertility enhancer. The effect of ethanolic extract of Cordia retusa on ethinyl estradiol induced infertility model with anovulation was examined. The extract at two different doses of 125 mg/kg as low dose and 250mg/kg as high dose were administered orally. The effect of extract on estrous cycle, serum FSH level, serum estrogen level, and fertility index were also evaluated to study the fertility intensifying activity. The high dose of ethanolic extract of Cordia retusa exhibited statistically a high significant (P<0.001) level in regularization of estrous cycle, statistically a high significant increase (P<0.001) in serum FSH level and serum estrogen level were observed when compared to negative control group. The high dose of ethanolic extract produced statistically a high significant (P<0.001) increase in number of newborns when compared to negative control group. The ethanolic extract from aerial parts of Cordia retusa induces fertility in female rats which were ethinyl estradiol induced anovulatory models.


Cite this article:
Murugesan Amudha, Shanmugam Rani. Fertility inducing activity of Cordia retusa in Female Albino rats. Asian J. Pharm. Res. 2020; 10(3):171-176. doi: 10.5958/2231-5691.2020.00030.1


REFERENCES:
1. Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys. PLOS Medicine. 2012; 9 (12): 1-12.
2. Kamel HH. Role of phyto-oestrogens in ovulation induction in women with polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol. 2013; 168: 60-63.
3. Guyton AC, Hall JE. Text Book of Medical Physiology. Unit XIV. Endocrinology and Reproduction 11th Ed. Elsevier Inc., Pennsylvania. 2006.
4. Ignacimuthu S, Ayyanar M, Sivaraman K. Ethnobotanical investigations among tribes in Madurai District of Tamil Nadu (India). J Ethnobiol Ethnomed. 2006; 2 (25): 1-7.
5. Rimando AM, Inoshiri S, Otsuka H, Kohda H, Yamasaki K, Padolina WG, Torres L, Quintana EG, Cantoria MC. Screening for mast cell histamine release inhibitory activity of Philippine medicinal plants active constituent of Ehretia microphylla. Japanese Journal of Pharamcognosy. 1987; 41 (3): 242-47.
6. Villasenor IM, Edu DA, Bremner JB. Structure of an antimutagen from Carmona retusa leaves. Carcinogenesis. 1993; 14 (1): 123-5.
7. Yamamura S, Simpol LR, Ozawa K, Ohtani K, Otsuka H, Kasai R, Yamasaki K, Padolina WG. Antiallergic dimericprenyl benzoquinones from Ehretia microphylla. Phytochemistry. 1995; 39 (1): 105-10.
8. Selvanayagam ZE, Gnanavendhan SG, Balakrishna K, Rao RB, Sivaraman J, Subramanian K, Puri R, Puri RK. Ehretianone, a novel quinonoid xanthene from Ehretia buxifolia with antisnake venom activity. J Nat Prod. 1996; 59 (7): 664-7.
9. Chandrappa CP, Govindappa M, Anilkumar NV, Channabasava R, Sadananda TS, Sharanappa P. In Vitro Anticancer activity of Quercetin isolated from Carmona retusa (Vahl.) Masam on Human Hepatoma Cell Line (Hepg2). IOSR Journal of Pharmacy and Biological Sciences. 2014; 9 (6): 85-91.
10. Villasenor IM, Canlas AP, Faustino KM, Plana KG. Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves. J Ethnopharmacol. 2004; 92 (1): 53-6.
11. Chandrappa CP, Govindappa M, Anil Kumar NV. Phytochemical screening and Antibacterial property of Carmona retusa (Vahl.) Masam. Int J Pharm Med and Bio Sc. 2012; 1 (2): 91-8.
12. OECD guideline for testing of chemicals 423 adopted 17th December 2001. Available from: URL: http:// www.oecd.org/ dataoecd/17/50/1948370.pdf
13. Bennink HJTC, Skouby S, Bouchard P, Holinka CF. Ovulation inhibition by estetrol in an in vivo model. Contraception. 2008; 77 (3): 186-190.
14. Rahman MA. Phytochemical and experimental study of Aparmaga (Achyranthus aspera Linn.) WSR to female anti-infertility activity. Presented for M.D (Ayurveda), Bangalore, Rajiv Gandhi University of Health Sciences, 2009.
15. Jadhav M, Menon S, Shailajan S. In vivo evaluation of Mimosa pudica Linn. in the management of polycystic ovary using rat model. Int J Appl Biol Pharm. 2012; 4 (1): 285-292.
16. Jha U, Asad M, Asdaq SMB, Das AK, Prasad VS. Fertility inducing effect of aerial parts of Coccinia cordifolia L. in female rats. J Ethnopharmacol. 2010; 127: 561-564.
17. Ugwah-Oguejiofor CJ, Bello SO, Okolo RU, Etuk EU, Ugwah MO, Igbokwe VU. Ficus platyphylla promotes fertility in female Rattus norvegicus Wistar strain: a preliminary study. Reprod Biol Endocrinol. 2011; 9 (145): 1-6.
18. Lienou LL, Telefo BP, Bale B, Yemele D, Tagne RS, Goka SC, Lemfack CM, Mouokeu C, Moundipa PF. Effect of the aqueous extract of Senecio biafrae (Oliv. and Hiern) J. Moore on sexual maturation of immature female rat. BMC Complement Altern Med. 2012; 12 (36): 1-9.
19. Mary F, Eswaramohan T, Surendran SN, Murugananthan A, Romakeswaran P. Mukkuddu Maathrai (Triple Tablet), An Indigenous Medicine Elevates Serum Prolactin Level of Female Rats (Rattus norvegicus). Journal of Pharmacy. 2013; 3 (1): 38-42.
20. Lembe DM, Gasco M, Gonzales GF. Fertility and estrogenic activity of Turraeanthus africanus in combination with Lepidium meyenii (Black maca) in female mice. Eur J Integr Med. 2012; 4: 345-51.
21. Shivalingappa H, Satyanarayan ND, Purohit MG, Sharanabasappa A, Patil SB. Effect of ethanol extract of Rivea hypocrateriformis on the estrous cycle of the rat. J Ethnopharmacol. 2002; 82: 11-7.
22. Uchendu CN, Kamalu TN, Asuzu IU. A preliminary evaluation of antifertility activity of a triterpenoid glycoside from Dalbergia saxatilis in female Wistar rats. Pharmacol Res. 2000; 41(5): 521-5.
23. Sarwar AHMD, Sharma S, Arif M, Thakur SS, Athar F, Khillare B, Thakur SC. Piper longum hexane fraction induces infertility by modulation of inflammatory mediators and gonadotropin insufficiency in female rats. Int J Pharm Pharm Sci. 2014; 6 (2): 416-20.
24. Rong-Zhen Z, Dao-Wei Z. Oxidative stress and role of natural plant derived antioxidants in animal reproduction. J Integr Agric. 2013; 12 (10): 1826-38.
25. Amudha M, Rani S. Molecular docking on the phytoconstituents of Cordia retusa (Vahl.) masam for its anti-infertility activity. World J Pharm Sci. 2014; 2 (12): 1905-09.
26. Bhutani KK, Jadhav AN, Kalia V. Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology. J Ethnopharmacol. 2004; 94: 197-200.
27. Mokhtari M, Sharifi E, Daneshi A. Effects of hydro-alcoholic extract of red dried stigmas of Crocus sativus L. flowers (saffron) on the levels of pituitary-ovary hormones and folliculogenesis in rats. Int J Fertil Steril. 2010; 3 (4): 185-190.
28. Watcho P, Ngadjui S, Alango NP, Benoît NT, Kamanyi A. Reproductive effects of Ficus asperifolia (Moraceae) in female rats. Afr Health Sci. 2009; 9 (1): 49-53.

Recomonded Articles:

Author(s): Mohite M S, Shelar P A, Raje V N., Babar S. J., Sapkal R. K.

DOI:         Access: Open Access Read More

Author(s): Deepa Amminbavi, N Prasanna Lakshmi

DOI: 10.5958/2231-5691.2020.00013.1         Access: Closed Access Read More

Author(s): Murugesan Amudha, Shanmugam Rani

DOI: 10.5958/2231-5691.2020.00030.1         Access: Closed Access Read More

Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


Recent Articles




Tags