Microwave assisted organic synthesis has as a new “lead” in the organic synthesis. The technique offers clean, simple, efficient, fast and economic for the synthesis of a number of organic molecules such reaction has new tool in the organic synthesis. Conventional method of organic synthesis usually requires longer heating time, tedious apparatus setup which result in higher cost of process and the excessive use of solvents or reagents lead to environmental pollution. This technique is considered as important approach toward green chemistry because this technique is more environments friendly and this technology is used in the laboratory and has the potential to have a large impact on the fields of combinatorial chemistry. The microwave reactions were performed using microwave assisted synthesis on microwave, the reactions were worked up extensively to obtain a pure form of product which was isolated using literature work-up procedures. The products were further recrystallized with suitable solvents. The reactions were monitored with TLC intermittently for microwave assisted synthesis and hourly for conventional method of synthesis.
Cite this article:
Akshay R. Yadav, Shrinivas K. Mohite, Chandrakant S. Magdum. Comparative Study of Conventional and Microwave Assisted Synthesis of some Organic Reactions. Asian J. Pharm. Res. 2020; 10(3):217-220. doi: 10.5958/2231-5691.2020.00037.4
1. Surati M, Jauhari S, Desai K, A Brief Review: Microwave assisted organic reaction. Arch. Appl. Sci. Res., 2012, 4(1):645-661.
2. Yadav A, Mohite S, Magdum C, Synthesis, Characterization and Biological Evaluation of Some Novel 1,3,4-Oxadiazole Derivatives as Potential Anticancer Agents, Int J Sci Res Sci Technol. March-April-2020; 7 (2): 275-282.
3. A K Nagariya, A K Meena, A K Yadav, U S Niranjan, A K Pathak, B Singh, M M Rao, Microwave assisted organic reaction as new tool in organic synthesis. J Pharm. Res. 2010, 3(3), 575-580.
4. Gaba M, Dhingra N, Microwave Chemistry: General features and Applications. Ind J Pharm Edu Res, 2011, 45(2): 175-183.
5. Gedye R, Smith F, Westaway K, The use of microwave ovens for rapid organic synthesis. Tetrahedron Lett. 1986; 27: 279-282.
6. Rajak H, Mishra P. Microwave assisted combinatorial chemistry: The potential approach for acceleration of drug discovery. J Sci Indus Res. 2004; 63:641-654.
7. Langa F, Cruz P, Hoz A, Ortiz A, Barra E. Microwave irradiation: more than just a method for accelerating reactions. Comtemp Org Synth. 1997; 4: 373-386.
8. Yadav A, Mohite S, Design, Synthesis and Characterization of Some Novel benzamide derivatives and it’s Pharmacological Screening. 2020. Int J Sci Res Sci Technol. 7(2): 68-74.
9. Gupta M, Paul S, Gupta R. General characteristics and applications of microwave in organic synthesis. Acta Chim Slov 2009; 56: 749-764.
10. Rajput M. D, Yadav A. R, Mohite S.K, Synthesis, Characterization of Benzimidazole Derivatives as Potent Antimicrobial Agents. 2020. Int. J. Pharm. 17(4): 279-285.
11. Joshi U J, Gokhale K M, Kantikar A P, Green chemistry: need for the hour, Ind. J. Edu. Res. 2011; 168-174.
12. Gasgnier M, Loupy A, Petit A, Jullien H, New developments in the field of energy transfer by means of monomade microwaves for various oxides and hydroxides. J. Alloys Comp. 1994; 204: 165-72.
13. Elander N, Jones JR, Lu SY, Stone-Elander S. Microwave-enhanced radiochemistry. Chem Soc Rev 2000; 29;239-249.
14. A. Tiwari, R. Kumar, A practical book of pharmaceutical medicinal chemistry. Nirali prakashan:38
15. Furniss B. S, Hanford A. J., Vogel’s textbook of practical chemistry, 5ed. Pearson education: 1989. P.1046-1047.
16. Gavarkar P. S, C. S. Magdum, S. K. Mohite, R. S. Adnaik, Practical’s in Medicinal Chemistry, 1ed. Unicorn publication: 47-82.
17. Jain K, Miniyar P, Nargud L, A Practical Book of Pharmaceutical Organic Chemistry, 1ed. Nirali Prakashan: 5.20-5.21.