ABSTRACT:
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5–10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS. Aim: To evaluate the comparative efficacy of the Pathadi Kwatha and Arogyavardhini vati and Kanchnaradi kwatha and Arogyavardhini vati in the management of various cutaneous manifestations in patients with PCOS. Settings and Design: The study was conducted in outpatient and inpatient unit of department of Prasuti tantra and Stree roga of National Institute of Ayurveda, Jaipur. Materials and Methods: The present study included 110 women of 18-40 years diagnosed to have PCOS according to Rotterdem revised criteria 2003. Hormonal analysis as well as radiological assessment was done in all the cases. out of 110 patients 50 patients each were divided in two groups (excluding drop outs) named Group A and Group B. Group A received Pathadi Kwatha and Arogyavardhini vati and Group B received Kanchnaradi kwatha and Arogyavardhini vati Results: In our study, Acne was found in 44% cases, Hirsutism in 84% cases, Alopecia, and Acanthosis nigri cans were present in 51%, and 34% patients respectively. In acne and hirsutism highly significant improvement was observed in both groups, and statistically insignificant result in Alopecia and acanthosis nigricans but percentage of relief is higher in Group A as compare to Group B. Conclusion: The trial drugs Pathadi kwatha and Arogyavardhini vati and Kanchanaradi kwatha and Arogyavardhini vati are equally effective in reducing Dermatologic manifestations of PCOS (Dhatvagnimandya Janya Beejagranthi Vikara).