Author(s): Ramchandra Jadhav, Kishor More, Dileep Khandekar, Ramesh Yamgar, Sudhir Sawant

Email(s): sawantsudhir@hotmail.com

DOI: Not Available

Address: Ramchandra Jadhav, Kishor More, Dileep Khandekar, Ramesh Yamgar and Sudhir Sawant*
Chemistry Research Laboratory, Patkar Varde College, Goregaon (West), Mumbai 400 062, India.
*Corresponding Author

Published In:   Volume - 1,      Issue - 1,     Year - 2011


ABSTRACT:
This paper deals with an efficient preparation of 2-Chloromethyl pyridine intermediate useful for preparation of pyridinylmethyl sulphinyl benzimidazole especially Rabeprazole sodium. In the present study, we have demonstrated a shorter route of synthesis for 2-Chloromethyl pyridine intermediate and in situ condensation with 2-Mercaptobenzimidazole to get Rabeprazole. This strategy is extremely advantageous from the commercial scale up point and would help in reducing the overall timeline and cost for the large scale manufacture of Rabeprazole sodium.


Cite this article:
Ramchandra Jadhav, Kishor More, Dileep Khandekar, Ramesh Yamgar, Sudhir Sawant. An Efficient Synthesis of Rabeprazole Sodium. Asian J. Pharm. Res. 1(1): Jan.-Mar. 2011; Page 13-16.


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Asian Journal of Pharmaceutical Research (AJPRes.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. AJPRes. publishes Original Research Articles, Short Communications..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5691 


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