Banned
Drugs: A Review
D.
Sunitha1*, K. Hemalatha2, M. Sudhakar1
1Malla Reddy College of Pharmacy (Osmania University),
Maisammaguda, Hyderabad, Telangana.
2Acharya B. M. Reddy College of Pharmacy, Bangalore,
Karnataka.
*Corresponding Author E-mail:
ABSTRACT:
Drugs are made to save lives and not cause deaths.
Every drug has some side effect if the dose of the drug is correct, then it can
be avoided. Some drugs side/ adverse effects can be reduced by another drug.
Hence, doctor prescribed medication is safer then self medication. Banned drugs
have more adverse/ side effects. Doctors should stop prescribing banned drugs
and due to less demand manufacturer will not produce such drugs. As well as the
government should make strict laws against the peoples involved in
manufacturing and selling of banned drugs. Government should be ordered to dump
these cheap drugs in proper manner. And also, India’s pharmacovigilance effort has to be
scaled up rapidly. People should say stop selling banned drugs.
KEY WORDS: Banned drugs, market,
committee, chemicals, Illegal drugs.
INTRODUCTION:
Drugs or medicines may
be withdrawn from commercial markets
because of risks to patients, but also because of commercial reasons (e.g. lack
of demand and relatively high production costs). Where risks or harms is the
reason for withdrawal, this will usually have been prompted by unexpected
adverse effects that were not detected during Phase III clinical
trials, i.e. they were only
made apparent from post marketing surveillance data collected from the wider community over longer periods of time.
Drugs are chemicals that change the way a person's
body works. If you are sick and had to take drug prescribed by doctor, it will
make you get well soon. Medicines are
legal drugs, meaning doctors are allowed to prescribe them for patients, stores
can sell them, and people are allowed to buy them. But it's not legal, or safe,
for people to use these medicines any way they want or to buy them from people
who are selling them illegally. Illegal drugs aren't good for anyone. These
drugs damage the brain, heart, and other important organs. Such illegal drugs
should be banned. Drugs have to pass from different phases of clinical trials
before they are introduced into the market. Firstly they undergoes animals
testing and then in human beings during clinical trials. During these different phases the efficacy as
well as safety profiles of the drug are tested. But yet some adverse effects of
drugs appear after their usage in the general population. Some drugs may cause adverse effects only
when combined with particular drugs.
These adverse effects are detected though a process of regular
monitoring after the drug is released called pharmacovigilance. If the adverse effects outweigh the benefits,
or if the drug is ineffective, the country may ban the drug and Company recall
that batch. Many spurious drugs that have been banned or withdrawn under
restrictions in other countries, but continued to be sold in India. The pharmaceutical companies are playing
with the lives of thousands of people who are not aware of the harmful effects
of the drugs they sell. In such cases, a
number of single drugs as well as fixed dose combinations have been banned for
manufacture, marketing and distribution in India. India is dumping ground for
banned drugs. India is one of the few countries that export huge amount of
banned drugs to other countries. Due to competition to become rich, many
defaulters pharmaceuticals have been set up and growing in every direction.
There are poor provision on check and control of spurious drugs in Indian
markets. Even a large number of population takes medicine and drugs without
prescribing a doctor which can be dangerous. More and more banned medicines are
finding their way in India. This list is not limited to drugs that were ever
approved by the FDA. Some of them (lumiracoxib, rimonabant, tolrestat,
ximelagatran and ximelidine, for example) were approved to be marketed in
Europe but had not yet been approved for marketing in the US, when side effects
became clear and their developers pulled them from the market. Some drugs in
this list (e.g. LSD) were never approved for marketing in the US or Europe.
List of the drugs withdrawn
from the country in particular year and its adverse effect:
Drug name |
Withdrawn |
Country |
Remarks |
Adderall XR |
2005 |
Canada |
Risk of stroke
[1] The ban was later lifted because the death rate among those taking
Adderall XR was determined to be no greater than those not taking Adderall. |
Alatrofloxacin |
2006 |
Worldwide |
Liver toxicity;
serious liver injury leading to liver transplant; death.[2] |
Alclofenac |
1979 |
UK |
Vasculitis,
Rash.[3] |
Alpidem (Ananxyl) |
1995 |
Worldwide |
Not approved in
the US, withdrawn in France in 1994[4] and the rest of the market in 1995
because of rare but serious hepatotoxicity.[3][5] |
Alosetron
(Lotronex) |
2000 |
US |
Serious
gastrointestinal adverse events; ischemic colitis; severe constipation.[2]
Reintroduced 2002 on a restricted basis |
Althesin
(=Alphaxolone amineptine + Alphadolone) |
1984 |
France, Germany,
UK |
Anaphylaxis.[3] |
Amineptine
(Survector) |
1999 |
France, US |
Hepatotoxicity,
dermatological side effects, and abuse potential.[6] Reason: |
Aminopyrine |
1999 |
France, Thailand |
Risk of
agranulocytosis; severe acne.[3] |
Amobarbital |
1980 |
Norway |
Self
poisoning.[3] |
Amoproxan |
1970 |
France |
Dermatologic and
ophthalmic toxicity.[3] |
Anagestone
acetate |
1969 |
Germany |
Animal
carcinogenicity.[3] |
Antrafenine |
1984 |
France |
Unspecific
experimental toxicity.[3] |
Aprotinin
(Trasylol) |
2008 |
US |
Increased risk of
death.[2] |
Ardeparin
(Normiflo) |
2001 |
US |
Not for reasons
of safety or efficacy.[7] |
Astemizole
(Hismanal) |
1999 |
US, Malaysia,
Multiple Nonspecified Markets |
Fatal
arrhythmia[2][3] |
Azaribine |
1976 |
US |
Thromboembolism.[3] |
Bendazac |
1993 |
Spain |
Hepatotoxicity.[3] |
Benoxaprofen |
1982 |
Germany,Spain,
UK, US |
Liver and kidney
failure; gastrointestinal bleeding; ulcers.[2][3] |
Benzarone |
1992 |
Germany |
Hepatitis.[3] |
Benziodarone |
1964 |
France, UK |
Jaundice.[3] |
Beta-ethoxy-lacetanilanide |
1986 |
Germany |
Renal toxicity,
animal carcinogenicity.[3] |
Bezitramide |
2004 |
Netherlands |
Fatal
overdose.[8] |
Bithionol |
1967 |
US |
Dermatologic
toxicity.[3] |
Broazolam |
1989 |
UK |
Animal
carcinogenicity.[3] |
Bromfenac |
1998 |
US |
Severe hepatitis
and liver failure (some requiring transplantation).[2] |
Bucetin |
1986 |
Germany |
Renal
toxicity.[3] |
Buformin |
1978 |
Germany |
Metabolic
toxicity.[3] |
Bunamiodyl |
1963 |
Canada, UK, US |
Nephropathy.[9] |
Butamben
(Efocaine)(Butoforme) |
1964 |
US |
Dermatologic
toxicity; psychiatric Reactions.[3] |
Canrenone |
1986 |
Germany |
Animal
Carcinogenicity.[3] |
Cerivastatin
(Baycol, Lipobay) |
2001 |
US |
Risk of
rhabdomyolysis[2] |
Chlormadinone
(Chlormenadione) |
1970 |
UK, US |
Animal
Carcinogenicity.[3] |
Chlormezanone
(Trancopal) |
1996 |
European Union,
US, South Africa, Japan |
Hepatotoxicity;
Steven-Johnson Syndrome; Toxic Epidermal Necrolysis.[3] |
Chlorphentermine |
1969 |
Germany |
Cardiovascular
Toxicity.[3] |
Cianidanol |
1985 |
France, Germany,
Spain, Sweden |
Hemolytic
Anemia.[3] |
Cinepazide |
1988 |
Spain |
Agranulocytosis.[10][11] |
Cisapride
(Propulsid) |
2000 |
US |
Risk of fatal
cardiac arrhythmias[2] |
Clioquinol |
1973 |
France, Germany,
UK, US |
Neurotoxicity.[3] |
Clobutinol |
2007 |
Germany |
Ventricular
arrhythmia, QT-prolongation.[12] |
Cloforex |
1969 |
Germany |
Cardiovascular
toxicity.[3] |
Clomacron |
1982 |
UK |
Hepatotoxicity.[3] |
Clometacin |
1987 |
France |
Hepatotoxicity.[3] |
Co-proxamol
(Distalgesic) |
2004 |
UK |
Overdose dangers. |
Cyclobarbital |
1980 |
Norway |
Self
poisoning.[3] |
Cyclofenil |
1987 |
France |
Hepatotoxicity.[3] |
Dantron |
1963 |
Canada, UK, US |
Genotoxicity.[13]
withdrawn from general use in UK but permitted in terminal patients |
Dexfenfluramine |
1997 |
European Union,
UK, US |
Cardiac valvular
disease.[3] |
Propoxyphene
(Darvocet/Darvon) |
2010 |
Worldwide |
Increased risk of
heart attacks and stroke.[14] |
Diacetoxydiphenolisatin |
1971 |
Australia |
Hepatotoxicity.[3] |
Diethylstilbestrol |
1970s |
Risk of
teratogenicity[citation needed] |
|
Difemerine |
1986 |
Germany |
Multi-Organ
toxicities.[3] |
Dihydrostreptomycin |
1970 |
US |
Neuropsychiatric
reaction.[3] |
Dilevalol |
1990 |
UK |
Hepatotoxicity.[3] |
Dimazole (Diamthazole) |
1972 |
France, US |
Neuropsychiatric
reaction.[3] |
Dimethylamylamine
(DMAA) |
1983 |
US |
Voluntarily
withdrawn from market by Lily.[15]:12 Reintroduced as a dietary supplement in
2006;[15]:13 and in 2013 the FDA started work to ban it due to cardiovascular
problems[16] |
Dinoprostone |
1990 |
UK |
Uterine
hypotonus, fetal distress.[3] |
Dipyrone(Metamizole) |
1975 |
UK, US, Others |
Agranulocytosis,
anaphylactic reactions.[3] |
Dithiazanine
iodide |
1964 |
France, US |
Cardiovascular
and metabolic reaction.[3] |
Dofetilide |
2004 |
Germany |
Drug
interactions, prolonged QT.[12] |
Drotrecogin alfa
(Xigris) |
2011 |
Worldwide |
Lack of efficacy
as shown by PROWESS-SHOCK study[17][18][19] |
Ebrotidine |
1998 |
Spain |
Hepatotoxicity.[3] |
Efalizumab
(Raptiva) |
2009 |
Germany |
Withdrawn because
of increased risk of progressive multifocal leukoencephalopathy[12] |
Encainide |
1991 |
UK, US |
Ventricular
arrhythmias.[2][3] |
Ethyl carbamate |
1963 |
Canada, UK, US, |
Carcinogenicity.[20] |
Etretinate |
1989 |
France |
Withdrawn US
(1999). Risk for birth defects.[2][3] |
Exifone |
1989 |
France |
Hepatotoxicity.[3] |
Fen-phen (popular
combination of fenfluramine and phentermine) |
1997 |
Cardiotoxicity |
|
Fenclofenac |
1984 |
UK |
Cutaneous
reactions; animal carcinogenicity.[3] |
Fenclozic acid |
1970 |
UK, US |
Jaundice,
elevated hepatic enzymes.[3] |
Fenfluramine |
1997 |
European Union,
UK, US, India, South Africa, others |
Cardiac valvular
disease, pulmonary hypertension, cardiac fibrosis.[3][21] |
Fenoterol |
1990 |
New Zealand |
Asthma
mortality.[3] |
Feprazone |
1984 |
Germany, UK |
Cutaneous
reaction, multiorgan toxicity.[3] |
Fipexide |
1991 |
France |
Hepatotoxicity.[3] |
Flosequinan
(Manoplax) |
1993 |
UK, US |
Increased
mortality at higher doses; increased hospitalizations.[2][3] |
Flunitrazepam |
1991 |
France |
Abuse.[3] |
Gatifloxacin |
2006 |
US |
Increased risk of
dysglycemia.[2] |
Gemtuzumab
ozogamicin (Mylotarg) |
2010 |
US |
No improvement in
clinical benefit; risk for death.[2] |
Glafenine |
1984 |
France, Germany |
Anaphylaxis.[3] |
Grepafloxacin
(Raxar) |
1999 |
Withdrawn
Germany, UK, US others |
Cardiac
repolarization; QT interval prolongation.[2] |
Hydromorphone
(Palladone, extended release version) |
2005 |
High risk of
accidental overdose when extended release version (Palladone) administered
with alcohol. Standard hydromorphone is sold in most of the world including
the US. |
|
Ibufenac |
1968 |
UK |
Hepatotoxicity,
jaundice.[3] |
Indalpine |
1985 |
France |
Agranulocytosis.[3] |
Indoprofen |
1983 |
Germany, Spain,
UK |
Animal
carcinogenicity, gastrointestinal toxicity.[3] |
Iodinated casein
strophantin |
1964 |
US |
Metabolic
reaction.[3] |
Iproniazid |
1964 |
Canada |
Interactions with
food products containing tyrosine.[22] |
Isaxonine
phosphate |
1984 |
France |
Hepatotoxicity.[3] |
Isoxicam |
1983 |
France, Germany,
Spain, others |
Stevens johnson
syndrome.[3] |
Kava Kava |
2002 |
Germany |
Hepatotoxicity.[12] |
Ketorolac |
1993 |
France, Germany,
others |
Hemorrhage, renal
Failure.[3] |
L-tryptophan |
1989 |
Germany, UK |
Eosinophilic
myalgia syndrome.[3] Still sold in the US |
Levamisole
(Ergamisol) |
1999 |
US |
Still used as
veterinary drug and as a human antihelminthic in many markets; listed on the
WHO List of Essential Medicines. In humans, it was used to treat melanoma
before it was withdrawn for agranulocytosis.[23][24][25] |
Levomethadyl
acetate |
2003 |
US |
Cardiac
arrhythmias and cardiac arrest.[2] |
Lumiracoxib
(Prexige) |
2007–2008 |
Worldwide |
Liver damage |
Lysergic acid
diethylamide (LSD) |
1950s–1960s |
Marketed as a
psychiatric drug; withdrawn after it became widely used recreationally. Now
illegal in most of the world. |
|
Mebanazine |
1975 |
UK |
Hepatotoxicity,
drug intereaction.[3] |
Methandrostenolone |
1982 |
France, Germany,
UK, US, others |
Off-label
abuse.[3] |
Methapyrilene |
1979 |
Germany, UK, US |
Animal
carcinogenicity.[3] |
Methaqualone |
1984 |
South Africa
(1971), India (1984), United Nations (1971-1988) |
Withdrawn because
of risk of addiction and overdose[26][27] |
Metipranolol |
1990 |
UK, others |
Uveitis.[3] |
Metofoline |
1965 |
US |
Unspecific
experimental toxicity.[3] |
Mibefradil |
1998 |
European Union,
Malaysia, US, others |
Fatal arrhythmia,
drug interactions.[2][3] |
Minaprine |
1996 |
France |
Convulsions.[3] |
Moxisylyte |
1993 |
France |
Necrotic
hepatitis.[3] |
Muzolimine |
1987 |
France, Germany,
European Union |
Polyneuropathy.[3] |
Natalizumab
(Tysabri) |
2005–2006 |
US |
Voluntarily
withdrawn from US market because of risk of Progressive multifocal
leukoencephalopathy (PML). Returned to market July, 2006. |
Nefazodone |
2007 |
US, Canada,
others |
Branded version
withdrawn by originator in several countries in 2007 for hepatotoxicity.
Generic versions available.[28] |
Nialamide |
1974 |
UK, US |
Hepatotoxicity,
drug intereaction.[3] |
Nikethamide |
1988 |
multiple markets |
CNS
Stimulation.[3] |
Nitrefazole |
1984 |
Germany |
Hepatic and
hematologic toxicity.[3] |
Nomifensine |
1981-1986 |
France, Germany,
Spain, UK, US, others |
Hemolytic Anemia,
hepatotoxicity, serious hypersensitive reactions.[2][3] |
Oxeladin |
1976 |
Canada, UK, US
(1976) |
Carcinogenicity.[29] |
Oxyphenbutazone |
1984-1985 |
UK, US, Germany,
France, Canada |
Bone marrow
suppression, Steven Johnson Syndrome.[3][30] |
Oxyphenisatin
(Phenisatin) |
Australia,
France, Germany, UK, US |
Hepatotoxicity.[3] |
|
Ozogamicin |
2010 |
US |
No improvement in
clinical benefit; risk for death; veno-occlusive disease.[2] |
Pemoline (Cylert) |
1997 |
Canada, UK |
Withdrawn from US
in 2005. Hepatotoxicity[31] Reason:hepatotoxicity.[3] |
Pentobarbital |
1980 |
Norway |
Self
poisoning.[3] |
Pentylenetetrazol |
1982 |
Withdrawn for
inability to produce effective convulsive therapy, and for causing seizures. |
|
Pergolide
(Permax) |
2007 |
US |
Risk for heart
valve damage.[2] |
Perhexilene |
1985 |
UK, Spain |
Neurologic and
hepatic toxicity.[3] |
Phenacetin |
1975 |
Canada |
An ingredient in
"A.P.C." tablet; withdrawn because of risk of cancer and kidney
disease[32] Germany Denmark, UK, US, others Reason: nephropathy.[3] |
Phenformin and
Buformin |
1977 |
France, Germany
US |
Severe lactic
acidosis[3] |
Phenolphthalein |
1997 |
US |
Carcinogenicity.[33] |
Phenoxypropazine |
1966 |
UK |
Hepatotoxicity,
drug intereaction.[3] |
Phenylbutazone |
1985 |
Germany |
Off-label abuse,
hematologic toxicity.[3] |
Phenylpropanolamine(Propagest,
Dexatrim) |
2000 |
Canada, US |
Hemorrhagic
stroke.[34][35] |
Pifoxime
(=Pixifenide) |
1976 |
France |
Neuropsychiatric
reaction.[3] |
Pirprofen |
1990 |
France, Germany,
Spain |
Liver
toxicity.[3][36]:223 |
Prenylamine |
1988 |
Canada, France,
Germany, UK, US, others |
Cardiac
arrythmia[37] and death.[3] |
Proglumide |
1989 |
Germany |
Respiratory
reaction.[3] |
Pronethalol |
1965 |
UK |
Animal
carcinogenicity.[3] |
Propanidid |
1983 |
UK |
Allergy.[3] |
Proxibarbal |
1998 |
Spain, France,
Italy, Portugal, Turkey |
Immunoallergic,
thrombocytopenia.[3] |
Pyrovalerone |
1979 |
France |
Abuse.[3] |
Rapacuronium
(Raplon) |
2001 |
US, multiple
markets |
Withdrawn in many
countries because of risk of fatal bronchospasm[2] |
Remoxipride |
1993 |
UK, others |
Aplastic
anemia.[3] |
Rimonabant
(Acomplia) |
2008 |
Worldwide |
Risk of severe
depression and suicide[12] |
Rofecoxib (Vioxx) |
2004 |
Worldwide |
withdrawn by MAH.
Risk of myocardial infarction and stroke[2] |
Rosiglitazone (Avandia) |
2010 |
Europe |
Risk of heart
attacks and death. This drug continues to be available in the US |
Secobarbital |
France, Norway,
others. |
Self
poisoning.[3] |
|
Sertindole |
1998 |
European Union |
Arrhythmia and
sudden cardiac death[3][38] |
Sibutramine
(Reductil/Meridia) |
2010 |
Australia,[39]
Canada,[40] China,[41] the European Union (EU),[42] Hong Kong,[43] India,[44]
Mexico, New Zealand,[45] the Philippines,[46] Thailand,[47] United
Kingdom,[48] and United States[49] |
Increased risk of
heart attack and stroke.[2] |
Sitaxentan |
2010 |
Germany |
Hepatotoxicity.[12] |
Sorivudine |
1993 |
Japan |
Drug interaction
and deaths.[50] |
Sparfloxacin |
2001 |
US |
QT prolongation
and phototoxicity.[2] |
Sulfacarbamide |
1988 |
Germany |
Dermatologic,
hematologic and hepatic reactions .[3] |
Sulfamethoxydiazine |
1988 |
Germany |
Unknown.[3] |
Sulfamethoxypyridazine |
1986 |
UK |
Dermatologic and
hematologic reactions.[3] |
Suloctidyl |
1985 |
Germany, France,
Spain |
Hepatotoxicity.[3] |
Suprofen |
1986-1987 |
UK, Spain, US |
Flank pain,
decreased kidney function.[2][3] |
Tegaserod
(Zelnorm) |
2007 |
US |
Risk for heart
attack, stroke, and unstable angina.[2] Was available through a restricted
access program until April 2008. |
Temafloxacin |
1992 |
Germany, UK, US,
others |
Low blood sugar;
hemolytic anemia; kidney, liver dysfunction; allergic reactions[2][3] |
Temafloxacin |
1992 |
US |
Allergic
reactions and cases of hemolytic anemia, leading to three patient deaths.[2] |
Temazepam
(Restoril, Euhypnos, Normison, Remestan, Tenox, Norkotral) |
1999 |
Sweden, Norway |
Diversion, abuse,
and a relatively high rate of overdose deaths in comparison to other drugs of
its group. This drug continues to be available in most of the world including
the US, but under strict controls. |
Terfenadine
(Seldane, Triludan) |
1997-1998 |
France, South
Africa, Oman, others, US |
Prolonged QT
interval; ventricular tachycardia[2][3] |
Terodiline
(Micturin) |
1991 |
Germany, UK,
Spain, others |
Prolonged QT
interval, ventricular tachycardia and arrhythmia.[3] |
Tetrazepam |
2013 |
European Union |
Serious cutaneous
reactions.[51] |
Thalidomide |
1961 |
Germany |
Withdrawn because
of risk of teratogenicity;[52] returned to market for use in leprosy and
multiple myeloma under FDA orphan drug rules |
Thenalidine |
1960 |
Canada, UK, US |
Neutropenia[3][53] |
Thiobutabarbitone |
1993 |
Germany |
Renal
insufficiency.[3] |
Thioridazine
(Melleril) |
2005 |
Germany, UK |
Withdrawn
worldwide due to severe cardiac arrhythmias[54][55] |
Ticrynafen(Tienilic
acid) |
1980 |
Germany, France,
UK, US others |
Liver toxicity
and death.[3] |
Tolcapone
(Tasmar) |
1998 |
European Union,
Canada, Australia |
Hepatotoxicity[3] |
Tolrestat
(Alredase) |
1996 |
Argentina,
Canada, Italy, others |
Severe
hepatotoxicity[3] |
Triacetyldiphenolisatin |
1971 |
Australia |
Hepatotoxicity.[3] |
Triazolam |
1991 |
France,
Netherlands, Finland, Argentina, UK others |
Psychiatric
adverse drug reactions, amnesia.[3][56] |
Triparanol |
1962 |
France, US |
Cataracts,
alopecia, ichthyosis.[3] |
Troglitazone
(Rezulin) |
2000 |
US, Germany |
Hepatotoxicity[2] |
Trovafloxacin
(Trovan) |
1999-2001 |
European Union,
US |
Withdrawn because
of risk of liver failure[2][3] |
Valdecoxib (Bextra) |
2004 |
US |
Risk of heart
attack and stroke.[2] |
Vincamine |
1987 |
Germany |
Hematologic
toxicity.[3] |
Xenazoic acid |
1965 |
France |
Hepatotoxicity.[3] |
Ximelagatran
(Exanta) |
2006 |
Germany |
Hepatotoxicity[12] |
Zimelidine |
1983 |
Worldwide |
Risk of
Guillain-Barré syndrome, hypersensitivity reaction, hepatotoxicity[3][57][58]
banned worldwide.[59] |
Zomepirac |
1983 |
UK, Germany,
Spain, US |
Anaphylactic
reactions and non-fatal allergic reactions, renal failure[2][3] |
The government has decided to prohibit manufacturing and sale of these
medicines because they were found to be "irrational" without any
therapeutic efficacy and use. Also, in some cases, there were concerns about
misuse of such medicines considered unsafe for mass consumption. The health
ministry has approved the ban order with immediate effect. A fixed dose
combination (FDC) is one that contains two or more drugs combined in a fixed
ratio of doses and available in a single dosage form. Health Ministry has to
release list of all banned drugs and it should be available easily to all
outlets, all media, newspapers including local language newspaper also explore
all names of the drugs banned. Health experts say many unapproved formulations
and FDCs are sold in India. Most of these medicines are in the analgesics,
anti-depressant and psychotic condition segment. Industry estimates suggest the
move is likely to impact pharmaceutical sales to the tune of around Rs 1,500
crore. A study published in 2015 in journal PLOS Medicine pointed that over 12%
of non-steroidal anti-inflammatory FDCs contain drugs that have either been
withdrawn from the market or have had their use restricted. For ensuring safety
and efficacy of medicines, the health ministry has banned around 350 fixed dose
combination (FDC) drugs that were widely available in the market till now.
These medicines include FDCs based on codeine, used in popular cough syrups
like Phensedyl and Corex.
Complete New List
of Banned Fixed Dose Combination (FDC) Drugs 2016:
·
FDC of
Aceclofenac + Paracetamol + Rabeprazole
·
Nimesulide
+ Diclofenac
·
Nimesulide
+ Cetirizine + Caffeine
·
Nimesulide
+ Tizanidine
·
Paracetamol
+ Cetirizine + Caffeine
·
Diclofenac
+ Tramadol + Chlorzoxazone
·
Dicyclomine
+ Paracetamol + Domperidone
·
Nimesulide
+ Paracetamol dispersible tablets
·
Paracetamol
+ Phenylephrine + Caffeine
·
Diclofenac
+ Tramadol + Paracetamol
·
Diclofenac
+ Paracetamol + Chlorzoxazone + Famotidine
·
Naproxen
+ Paracetamol
·
Nimesulide
+ Serratiopeptidase
·
Paracetamol
+ Diclofenac + Famotidine
·
Nimesulide
+ Pitofenone + Fenpiverinium + Benzyl Alcohol
·
Omeprazole
+ Paracetamol + Diclofenac
·
Nimesulide
+ Paracetamol injection
·
Tamsulosin
+ Diclofenac
·
Paracetamol
+ Phenylephrine + Chlorpheniramine + Dextromethorphan + Caffeine
·
Diclofenac
+ Zinc Carnosine
·
Diclofenac
+ Paracetamol + Chlorpheniramine Maleate + Magnesium Trisilicate
·
Paracetamol
+ Pseudoephedrine + Cetirizine
·
Phenylbutazone
+ Sodium Salicylate
·
Lornoxicam
+ Paracetamol + Trypsin
·
Paracetamol
+ Mefenamic Acid + Ranitidine + Dicyclomine
·
Nimesulide
+ Dicyclomine
·
Heparin
+ Diclofenac
·
Glucosamine
+ Methylsulfonylmethane + Vitamin D3 + Manganese + Boron + Copper +
Zinc
·
Paracetamol
+ Tapentadol
·
Tranexamic
Acid + Proanthocyanidin
·
Benzoxonium
Chloride + Lidocaine
·
Lornoxicam
+ Paracetamol + Tramadol
·
Lornoxicam
+ Paracetamol + Serratiopeptidase
·
Diclofenac
+ Paracetamol + Magnesium Trisilicate
·
Paracetamol
+ Domperidone + Caffeine
·
Ammonium
Chloride + Sodium Citrate + Chlorpheniramine Maleate + Menthol
·
Paracetamol
+ Prochlorperazine Maleate
·
Combikit
of 3 tablets of Serratiopeptidase (enteric coated 20000 units) + Diclofenac
Potassium and 2 tablets of Doxycycline
·
Nimesulide
+ Paracetamol Suspension
·
Aceclofenac
+ Paracetamol + Famotidine
·
Aceclofenac
+ Zinc Carnosine
·
Paracetamol
+ Disodium Hydrogen Citrate + Caffeine
·
Paracetamol
+ DL Methionine
·
Disodium
Hydrogen Citrate + Paracetamol
·
Paracetamol
+ Caffeine + Codeine
·
Aceclofenac
(SR) + Paracetamol
·
Diclofenac
+ Paracetamol injection
·
Azithromycin
+ Cefixime
·
Amoxicillin
+ Dicloxacillin
·
Amoxicillin
250 mg + Potassium Clavulanate Diluted 62.5 mg
·
Azithromycin
+ Levofloxacin
·
Cefixime
+ Linezolid
·
Amoxicillin
+ Cefixime + Potassium Clavulanic Acid
·
Ofloxacin
+ Nitazoxanide
·
Cefpodoxime
Proxetil + Levofloxacin
·
Combikit
of Azithromycin, Secnidazole and Fluconazole
·
Levofloxacin
+ Ornidazole + Alpha Tocopherol Acetate
·
Nimorazole
+ Ofloxacin
·
Azithromycin
+ Ofloxacin
·
Amoxycillin
+ Tinidazole
·
Doxycycline
+ Serratiopeptidase
·
Cefixime
+ Levofloxacin
·
Ofloxacin
+ Metronidazole + Zinc Acetate
·
Diphenoxylate
+ Atropine + Furazolidone
·
Combikit
of Fluconazole Tablet, Azithromycin Tablet and Ornidazole Tablets
·
Ciprofloxacin
+ Phenazopyridine
·
Amoxycillin
+ Dicloxacillin + Serratiopeptidase
·
Combikit
of Fluconazole Tablet, Azithromycin Tablet and Ornidazole Tablets
·
Ciprofloxacin
+ Phenazopyridine
·
Amoxycillin
+ Dicloxacillin + Serratiopeptidase
·
Azithromycin
+ Cefpodoxime
·
Lignocaine
+ Clotrimazole + Ofloxacin + Beclomethasone
·
Cefuroxime
+ Linezolid
·
Ofloxacin
+ Ornidazole + Zinc Bisglycinate
·
Metronidazole
+ Norfloxacin
·
Amoxicillin
+ Bromhexine
·
Ciprofloxacin
+ Fluticasone + Clotrimazole + Neomycin
·
Metronidazole
+ Tetracycline
·
Cephalexin
+ Neomycin + Prednisolone
·
Azithromycin
+ Ambroxol
·
Cilnidipine
+ Metoprolol Succinate + Metoprolol Tartrate
·
L-Arginine
+ Sildenafil
·
Atorvastatin
+ Vitamin D3 + Folic Acid + Vitamin B12 + Pyridoxine
·
Metformin
+ Atorvastatin
·
Clindamycin
+ Telmisartan
·
Olmesartan
+ Hydrochlorothiazide + Chlorthalidone
·
L-5-Methyltetrahydrofolate Calcium + Escitalopram i
·
Pholcodine
+ Promethazine
·
Paracetamol
+ Promethazine
·
Betahistine
+ Ginkgo Biloba Extract + Vinpocetine + Piracetam\ Cetirizine + Diethyl
Carbamazine
·
Doxylamine
+ Pyridoxine + Mefenamic Acid + Paracetamol
·
Drotaverine
+ Clidinium + Chlordiazepoxide
·
Imipramine
+ Diazepam
·
Flupentixol
+ Escitalopram
·
Paracetamol
+ Prochlorperazine
·
Gabapentin
+ Mecobalamin + Pyridoxine + Thiamine
·
Imipramine
+ Chlordiazepoxide + Trifluoperazine + Trihexyphenidyl
·
Chlorpromazine
+ Trihexyphenidyl
·
Ursodeoxycholic
Acid + Silymarin
·
Metformin
1000/1000/500/500 mg + Pioglitazone 7.5/7.5/7.5/7.5mg + Glimepiride 1/2/1/2 mg
·
Gliclazide
80 mg + Metformin 325 mg
·
Voglibose+
Metformin + Chromium Picolinate
·
Pioglitazone
7.5/7.5mg + Metformin 500/1000mg
·
Glimepiride
1mg/2mg/3mg + Pioglitazone 15mg/15mg/15mg + Metformin 1000mg/1000mg/1000mg
·
Glimepiride
1 mg/2mg+ Pioglitazone 15mg/15mg + Metformin 850mg/850mg
·
Metformin
850mg + Pioglitazone 7.5 mg + Glimepiride 2 mg
·
Metformin
850mg + Pioglitazone 7.5 mg + Glimepiride 1 mg
·
Metformin
500mg/500mg+Gliclazide SR 30mg/60 mg + Pioglitazone 7.5mg/7.5mg
·
Voglibose
+ Pioglitazone + Metformin
·
Metformin
+ Bromocriptine
·
Metformin
+ Glimepiride + Methylcobalamin
·
Pioglitazone
30 mg + Metformin 500 mg
·
Glimepiride
+ Pioglitazone + Metformin
·
Glipizide
2.5mg + Metformin 400 mg
·
Pioglitazone
15mg + Metformin 850 mg
·
Metformin
ER + Gliclazide MR + Voglibose
·
Chromium
Polynicotinate + Metformin
·
Metformin
+ Gliclazide + Pioglitazone + Chromium Polynicotinate
·
Metformin
+ Gliclazide + Chromium Polynicotinate
·
Glibenclamide
+ Metformin (SR)+ Pioglitazone
·
Metformin
(Sustained Release) 500mg + Pioglitazone 15 mg + Glimepiride 3mg
·
Metformin
(SR) 500mg + Pioglitazone 5mg
·
Chloramphenicol
+ Beclomethasone + Clotrimazole + Lignocaine
·
Clotrimazole
+ Ofloxacin + Lignocaine + Glycerine and Propylene Glycol
·
Chloramphenicol
+ Lignocaine + Betamethasone + Clotrimazole + Ofloxacin + Antipyrine
·
Ofloxacin
+ Clotrimazole + Betamethasone + Lignocaine
·
Gentamicin
Sulphate + Clotrimazole + Betamethasone + Lignocaine
·
Clotrimazole
+ Beclomethasone + Ofloxacin + Lignocaine
·
Beclomethasone
+ Clotrimazole + Chloramphenicol + Gentamycin + Lignocaine Ear drops
·
Flunarizine
+ Paracetamol + Domperidone
·
Rabeprazole
+ Zinc Carnosine
·
Magaldrate
+ Famotidine + Simethicone
·
Cyproheptadine
+ Thiamine
·
Magaldrate
+ Ranitidine + Pancreatin + Domperidone
·
Ranitidine
+ Magaldrate + Simethicone
·
Magaldrate
+ Papain + Fungal Diastase + Simethicone
·
Rabeprazole
+ Zinc + Domperidone
·
Famotidine
+ Oxetacaine + Magaldrate
·
Ranitidine
+ Domperidone + Simethicone
·
Alginic
Acid + Sodium Bicarbonate + Dried Aluminium Hydroxide + Magnesium Hydroxide
·
Clidinium
+ Paracetamol + Dicyclomine + Activated Dimethicone
·
Furazolidone
+ Metronidazole + Loperamide
·
Rabeprazole
+ Diclofenac + Paracetamol
·
Ranitidine
+ Magaldrate
·
Norfloxacin
+ Metronidazole + Zinc Acetate
·
Zinc
Carnosine + Oxetacaine
·
Oxetacaine
+ Magaldrate + Famotidine
·
Pantoprazole
(as Enteric Coated Tablet) + Zinc Carnosine (as Film Coated Tablets)
·
Zinc
Carnosine + Magnesium Hydroxide + Dried Aluminium Hydroxide + Simethicone
·
Zinc
Carnosine + Sucralfate
·
Mebeverine
and Inner HPMC capsule (Streptococcus Faecalis + Clostridium butyricum +
Bacillus mesentericus + Lactic Acid Bacillus)
·
Clindamycin
+ Clotrimazole + Lactic Acid Bacillus
·
Sildenafil
+ Estradiol Valerate
·
Clomiphene
Citrate + Ubidecarenone + Zinc + Folic Acid + Methylcobalamin + Pyridoxine +
Lycopene + Selenium + Levocarnitine Tartrate + L-Arginine
·
Thyroxine
+ Pyridoxine + Folic Acid
·
Gentamycin
+ Dexamethasone + Chloramphenicol + Tobramycin + Ofloxacin
·
Dextromethorphan
+ Levocetirizine + Phenylephrine + Zinc
·
Nimesulide
+ Loratadine + Phenylephrine + Ambroxol
·
Bromhexine
+ Phenylephrine + Chlorpheniramine Maleate
·
Dextromethorphan
+ Bromhexine + Guaiphenesin
·
Paracetamol
+ Loratadine + Phenylephrine + Dextromethorphan + Caffeine
·
Nimesulide
+ Phenylephrine + Caffeine + Levocetirizine
·
Azithromycin
+ Acebrophylline
·
Diphenhydramine
+ Terpene + Ammonium Chloride + Sodium Chloride + Menthol
·
Nimesulide
+ Paracetamol + Cetirizine + Phenylephrine
·
Paracetamol
+ Loratadine + Dextromethorphan + Pseudoephedrine + Caffeine
·
Chlorpheniramine
Maleate + Dextromethorphan + Dextromethorphan + Guaiphenesin + Ammonium
Chloride + Menthol
·
Chlorpheniramine
Maleate + Ammonium Chloride + Sodium Citrate
·
Cetirizine
+ Phenylephrine + Paracetamol + Zinc Gluconate
·
Ambroxol
+ Guaiphenesin + Ammonium Chloride + Phenylephrine + Chlorpheniramine Maleate +
Menthol
·
Dextromethorphan
+ Bromhexine + Chlorpheniramine Maleate + Guaiphenesin
·
Levocetirizine
+ Ambroxol + Phenylephrine + Guaiphenesin
·
Dextromethorphan
+ Chlorpheniramine + Chlorpheniramine Maleate
·
Cetirizine
+ Ambroxol + Guaiphenesin + Ammonium Chloride + Phenylephrine + Menthol
·
Chlorpheniramine
+ Phenylephrine + Caffeine
·
Dextromethorphan
+ Triprolidine + Phenylephrine
·
Terpin
Hydrate + Dextromethorphan + Menthol
·
Dextromethorphan
+ Phenylephrine + Zinc Gluconate + Menthol
·
Chlorpheniramine
+ Codeine + Sodium Citrate + Menthol Syrup
·
Enrofloxacin
+ Bromhexine
·
Bromhexine
+ Dextromethorphan + Phenylephrine + Menthol
·
Levofloxacin
+ Bromhexine
·
Levocetirizine
+ Ranitidine
·
Levocetirizine
+ Phenylephrine + Ambroxol + Guaiphenesin + Paracetamol
·
Cetirizine
+ Dextromethorphan + Phenylephrine + Zinc Gluconate + Paracetamol + Menthol
·
Paracetamol
+ Pseudoephedrine + Dextromethorphan + Cetirizine
·
Diphenhydramine
+ Guaiphenesin + Ammonium Chloride + Bromhexine
·
Chlorpheniramine
+ Dextromethorphan + Phenylephrine + Paracetamol
·
Dextromethorphan
+ Promethazine
·
Diethylcarbamazine
Citrate + Cetirizine + Guaiphenesin
·
Pseudoephedrine
+ Dextromethorphan + Cetirizine
·
Chlorpheniramine
+ Phenylephrine + Dextromethorphan + Menthol
·
Ambroxol
+ Terbutaline + Dextromethorphan
·
Dextromethorphan
+ Chlorpheniramine + Guaiphenesin
·
Terbutaline
+ Bromhexine + Guaiphenesin + Dextromethorphan
·
Dextromethorphan
+ Triprolidine + Phenylephrine
·
Paracetamol
+ Dextromethorphan + Chlorpheniramine
·
Pholcodine
+ Phenylephrine + Promethazine
·
Codeine
+ Levocetirizine + Menthol
·
Dextromethorphan
+ Ambroxol + Guaifenesin + Phenylephrine + Chlorpheniramine
·
Cetirizine
+ Phenylephrine + Dextromethorphan + Menthol
·
Roxithromycin
+ Serratiopeptidase
·
Paracetamol
+ Phenylephrine + Triprolidine
·
Acetaminophen
+ Loratadine + Ambroxol + Phenylephrine
·
Cetirizine
+ Acetaminophen + Dextromethorphan + Phenylephrine + Zinc Gluconate
·
Diphenhydramine
+ Guaifenesin + Bromhexine + Ammonium Chloride + Menthol Chlorpheniramine
Maleate + Codeine Syrup
·
Cetirizine
+ Dextromethorphan + Zinc Gluconate + Menthol
·
Paracetamol
+ Phenylephrine + Desloratadine + Zinc Gluconate + Ambroxol
·
Levocetirizine
+ Montelukast + Acebrophylline
·
Dextromethorphan
+ Phenylephrine + Ammonium Chloride + Menthol
·
Dextromethorphan
+ Bromhexine + Guaiphenesin + Menthol
·
Acrivastine
+ Paracetamol + Caffeine + Phenylephrine
·
Naphazoline
+ Carboxymethyl Cellulose + Menthol + Camphor + Phenylephrine
·
Dextromethorphan
+ Cetirizine
·
Nimesulide
+ Paracetamol + Levocetirizine + Phenylephrine + Caffeine
·
Terbutaline
+ Ambroxol + Guaiphenesin + Zinc + Menthol
·
Codeine
+ Chlorpheniramine + Alcohol Syrup
·
Dextromethorphan
+ Phenylephrine + Guaifenesin + Triprolidine
·
Ammonium
Chloride + Bromhexine + Dextromethorphan
·
Diethylcarbamazine
+ Cetirizine + Ambroxol
·
Ethyl
morphine + Noscapine + Chlorpheniramine
·
Cetirizine
+ Dextromethorphan + Ambroxol
·
Bromhexine
+ Dextromethorphan + Ammonium Chloride + Menthol
·
Ambroxol
+ Guaifenesin + Phenylephrine + Chlorpheniramine
·
Paracetamol
+ Phenylephrine + Chlorpheniramine + Zinc Gluconate
·
Dextromethorphan
+ Phenylephrine + Cetirizine + Paracetamol + Caffeine
·
Dextromethorphan
+ Chlorpheniramine + Guaifenesin + Ammonium Chloride
·
Levocetirizine
+ Dextromethorphan + Zinc
·
Paracetamol
+ Phenylephrine + Levocetirizine + Caffeine
·
Chlorpheniramine
+ Ammonium Chloride + Sodium Chloride
·
Paracetamol
+ Dextromethorphan + Bromhexine + Phenylephrine + Diphenhydramine
·
Salbutamol
+ Bromhexine + Guaiphenesin + Menthol
·
Chlorpheniramine
+ Ammonium Chloride + Noscapine + Sodium Citrate
·
Cetirizine
+ Dextromethorphan + Bromhexine + Guaifenesin
·
Diethylcarbamazine
+ Chlorpheniramine + Guaifenesin
·
Ketotifen
+ Cetirizine
·
Terbutaline
+ Bromhexine + Etophylline
·
Ketotifen
+ Theophylline
·
Ambroxol
+ Salbutamol + Theophylline
·
Cetirizine
+ Nimesulide + Phenylephrine
·
Chlorpheniramine
+ Phenylephrine + Paracetamol + Zinc Gluconate
·
Acetaminophen
+ Guaifenesin + Dextromethorphan + Chlorpheniramine
·
Cetirizine
+ Dextromethorphan + Phenylephrine + Tulsi
·
Cetirizine
+ Phenylephrine + Paracetamol + Ambroxol + Caffeine
·
Guaifenesin
+ Dextromethorphan
·
Levocetirizine
+ Paracetamol + Phenylephrine + Caffeine
·
Caffeine
+ Paracetamol + Phenylephrine + Chlorpheniramine
·
Ketotifen
+ Levocetirizine
·
Paracetamol
+ Levocetirizine + Phenylephrine + Zinc Gluconate
·
Paracetamol
+ Phenylephrine + Triprolidine + Caffeine
·
Caffeine
+ Paracetamol + Phenylephrine + Cetirizine
·
Caffeine
+ Paracetamol + Chlorpheniramine
·
Ammonium
Chloride + Dextromethorphan + Cetirizine + Menthol
·
Dextromethorphan
+ Paracetamol + Cetirizine + Phenylephrine
·
Chlorpheniramine
+ Terpin + Antimony Potassium Tartrate + Ammonium Chloride + Sodium Citrate +
Menthol
·
Terbutaline
+ Etofylline + Ambroxol
·
Paracetamol
+ Codeine + Chlorpheniramine
·
Paracetamol
+ Pseudoephedrine + Cetirizine + Caffeine
·
Chlorpheniramine+Ammonium
Chloride + Menthol
·
N-Acetylcysteine
+ Ambroxol + Phenylephrine + Levocetirizine
·
Dextromethorphan
+ Phenylephrine + Triprolidine + Menthol
·
Salbutamol
+ Cetirizine + Ambroxol
·
Dextromethorphan
+ Phenylephrine + Bromhexine + Guaifenesin + Chlorpheniramine
·
Nimesulide
+ Cetirizine + Phenylephrine
·
Naphazoline
+ Chlorpheniramine + Zinc Sulphate + Boric Acid + Sodium Chloride +
Chlorobutanol
·
Paracetamol
+ Bromhexine + Phenylephrine + Chlorpheniramine + Guaifenesin
·
Salbutamol
+ Bromhexine
·
Dextromethorphan
+ Phenylephrine + Guaifenesin + Cetirizine + Acetaminophen
·
Guaifenesin
+ Bromhexine + Chlorpheniramine + Paracetamol
·
Chlorpheniramine
+ Ammonium Chloride + Chloroform + Menthol
·
Salbutamol
+ Choline Theophyllinate + Ambroxol
·
Chlorpheniramine
+ Codeine Phosphate + Menthol Syrup
·
Pseudoephedrine
+ Bromhexine
·
Cetirizine
+ Phenylephrine + Paracetamol + Caffeine + Nimesulide
·
Dextromethorphan
+ Cetirizine + Guaifenesin + Ammonium Chloride
·
Ambroxol
+ Salbutamol + Choline Theophyllinate + Menthol
·
Paracetamol
+ Chlorpheniramine + Ambroxol + Guaifenesin + Phenylephrine
·
Chlorpheniramine
+ Vasaka + Tolubalsm + Ammonium Chloride + Sodium Citrate + Menthol
·
Bromhexine
+ Cetrizine + Phenylephrine IP+Guaifenesin + Menthol
·
Dextromethorphan
+ Ambroxol + Ammonium Chloride + Chlorpheniramine + Menthol
·
Dextromethorphan
+ Phenylephrine + Cetirizine + Zinc + Menthol
·
Terbutaline
+ N-Acetyl L-Cysteine + Guaifenesin
·
Calcium
Gluconate + Levocetirizine
·
Paracetamol
+ Levocetirizine + Pseudoephedrine
·
Salbutamol
+ Choline Theophyllinate + Carbocisteine
·
Chlorpheniramine
+ Vitamin C
·
Calcium Gluconate + Chlorpheniramine + Vitamin C
·
Chlorpheniramine
+ Paracetamol + Pseudoephedrine + Caffeine
·
Guaifenesin
+ Bromhexine + Chlorpheniramine + Phenylephrine + Paracetamol +
Serratiopeptidase (as enteric coated granules) 10000 SP Units
·
Paracetamol
+ Pheniramine
·
Betamethasone
+ Fusidic Acid + Gentamycin + Tolnaftate + lodochlorhydroxyquinoline (ICHQ)
·
Clobetasol
+ Ofloxacin + Miconazole + Zinc Sulphate
·
Clobetasole
+ Gentamicin + Miconazole + Zinc Sulphate
·
Levocetirizine
+ Ambroxol + Phenylephrine + Paracetamol
·
Permethrin
+ Cetrimide + Menthol
·
Beclomethasone
+ Clotrimazole + Neomycin + lodochloro hydroxyquinone Neomycin + Doxycycline
·
Ciprofloxacin
+ Fluocinolone + Clotrimazole + Neomycin + Chlorocresol
·
Clobetasol
+ Ofloxacin + Ketoconazole + Zinc Sulphate
·
Betamethasone
+ Gentamicin + Tolnaftate + lodochlorhydroxyquinoline
·
Clobetasol
+ Gentamicin + Tolnaftate + lodochlorhydroxyquinone + Ketoconazole
·
Allantoin
+ Dimethicone + Urea + Propylene + Glycerin + Liquid Paraffin
·
Acriflavine
+ Thymol + Cetrimide
·
Betamethasone
+ Neomycin + Tolnaftate + lodochlorohydroxyquinoline + Cholorocresol
·
Clobetasol
+ Neomycin + Miconazole + Clotrimazole
·
Ketoconazole
+ Tea Tree oil + Allantoin + Zinc Oxide + Aloe Vera + Jojoba oil + Lavender oil
+ Soba noodles
·
Clobetasol
Propionate + Ofloxacin + Ornidazole + Terbinafine
·
Clobetasol
+ Neomycin + Miconazole + Zinc Sulphate
·
Beclomethasone
Dipropionate + Neomycin + Tolnaftate + lodochlorhydroxyquinoline + Chlorocresol
·
Betamethasone
+ Gentamycin + Zinc Sulphate + Clotrimazole + Chlorocresol
·
Borax
+ Boric Acid + Naphazoline + Menthol + Camphor + Methyl Hydroxy Benzoate
·
Bromhexine
+ Dextromethorphan
·
Dextromethorphan
+ Chlorpheniramine + Bromhexine
·
Menthol
+ Anesthetic Ether
·
Dextromethorphan
+ Chlorpheniramine + Ammonium + Sodium Citrate + Menthol
·
Ergotamine
Tartrate + Belladonna Dry Extract+Caffeine + Paracetamol
·
Phenytoin
+ Phenobarbitone
·
Gliclazide
40mg + Metformin 400mg
·
Paracetamol
+ Ambroxol + Phenylephrine + Chlorpheniramine
·
Ofloxacin
+ Ornidazole Suspension
·
Albuterol
+ Etofylline + Bromhexine + Menthol
·
Albuterol
+ Bromhexine + Theophylline
·
Salbutamol+Hydroxyethyl
Theophylline (Etofylline) + Bromhexine
·
Paracetamol+Phenylephrine+Levocetirizine+Sodium
Citrate
·
Paracetamol
+ Propyphenazone + Caffeine
·
Guaifenesin
+ Diphenhydramine + Bromhexine + Phenylephrine
·
Dried
Aluminum Hydroxide Gel + Propantheline + Diazepam
·
Bromhexine
+ Phenylephrine + Chlorpheniramine + Paracetamol
·
Beclomethasone
+ Clotrimazole + Gentamicin + lodochlorhydroxyquinoline
·
Telmisartan
+ Metformin
·
Ammonium
Citrate + Vitamin B 12 + Folic Acid + Zinc Sulphate
·
Levothyroxine
+ Pyridoxine + Nicotinamide
·
Benfotiamine
+ Metformin
·
Thyroid
+ Thiamine + Riboflavin + Pyridoxine + Calcium Pantothenate + Tocopheryl
Acetate + Nicotinamide
·
Ascorbic
Acid + Menadione Sodium Bisulfite + Rutin + Dibasic Calcium Phosphate +
Adrenochrome mono Semicarbazone
·
Phenylephrine
+ Chlorpheniramine + Paracetamol + Bromhexine + Caffeine
·
Clotrimazole
+ Beclomethasone + Lignocaine + Ofloxacin + Acetic Acid + Sodium Methyl Paraben
+ Propyl Paraben
Health Ministry of India finalized that if any drug banned by two or more
countries and it is still being marketed in India, they may possibly remove the
drug from the Indian market after proper examination or appropriate action will
be taken. The Ministry of Health and Family Welfare had constituted an Expert
Committee under the Chairmanship of Prof. Ranjit Roy Chaudhury to formulate
policy and guidelines for approval of new drugs, clinical trials and banning of
drugs. The Expert Committee submitted its report to the Ministry of Health and
Family Welfare. Unacceptably large number of formulations, around 60,000 to
85,000 are banned by the committee.
Many of these medicines should not have been allowed to reach the market
in the first place. The committee asked to remove drugs which should never have
been allowed to reach the market is being marketed. Many of these drugs are
inherently unsafe and potentially hazardous. They do not appear in any textbook
of medicine or pharmacology; nor do they find a place in the market of any
country. Expert Committee also recommended that if the drug is already in the
market but two or more countries remove the drug from their market on grounds
of efficacy and safety, then the national drug regulatory agency should
consider the possibility of removing the drug from the Indian market as well.
It has been decided that if two or more countries remove a drug from their
market on grounds of efficacy and safety, then the continued marketing of the
drug in the country will be considered for examination and appropriate action.
CONCLUSION:
Large numbers of drugs are
banned by most of European countries but still they are easily available in
Indian market. Long term use of such medicines can put negative impact on human
health in various ways by damaging liver, kidney or any other organ,
depression, blood pressure fluctuations etc. A ban is needed to protect the
public’s health and the quality of health care. A ban will require
self-examination by the public, health care professions, pharmacist and the
health care policy community. As vigilant citizens of this country, we need to
keep your eyes and ears open and watch out for the kind of drugs we or our
loved ones consume. India and Indians need to wake up before it is too late.
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Received on 17.06.2016 Accepted on 30.06.2016
© Asian Pharma Press All Right Reserved
Asian J. Pharm.
Res. 2016; 6(4): 205-216.
DOI: 10.5958/2231-5691.2016.00029.0