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Asian Journal of Pharmaceutical Research
ISSN: 2231-5691(Online), 2231-5683(Print)
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Absorbance Ratio Method of Vortioxetine and Aripiprazole in Synthetic Mixture by UV Spectrophotometry
Ancy Mathew1, Suresh Kumar1*, Vishnu Sutariya2, Dhara Vashi1
1Department of Pharmaceutical Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat-394110, Gujarat, India.
2Shree Dhanvantary Pharmaceutical Analysis and Research Centre, Managed by- Ribosome Pharma Pvt.Ltd., Surat- 394110, Gujarat, India.
The absorbance ratio method is a modification of the simultaneous equations procedure. In this study, absorbance ratio analytical method is developed in UV spectrophotometry of Vortioxetine and Aripiprazole in synthetic mixture. The measurements were carried out at wavelengths of 225 and 255 nm. The 255nm is the ?max of Aripiprazole & 225nm is the isobestic point. The linear correlation of Isobestic point (r²=0.997) was obtained in the range of 2-20 µg/ml and for Aripiprazole the linear correlation range (r²=0.998) was obtained in the range of 2-32 µg/ml. The method was successfully used for absorbance ratio method of Vortioxetine and Aripiprazole in synthetic mixture form without any interference from excipients and prior separation.
Vortioxetine, Aripiprazole, UV visible spectrophotometry, Method Validation, absorbance ratio method.
Ancy Mathew, Suresh Kumar, Vishnu Sutariya, Dhara Vashi. Absorbance Ratio Method of Vortioxetine and Aripiprazole in Synthetic Mixture by UV Spectrophotometry. Asian J. Pharm. Res. 2019; 9(2): 63-68.
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