Volume No. :   9

Issue No. :  1

Year :  2019

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Formulation and Evaluation of Immediate Release Tablet of Efavirenz by Micellar Solubilization Technique



Address:   Snehal B. Kulkarni1*, Mr. M. M. Bari1, Dr. S. D. Barhate1, Ashutosh Tripathi2
1Department of Pharmaceutics, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Maharashtra, India, 424206 2Centurion Laboratories, Vadodara, Gujarat.
*Corresponding Author
DOI No: 10.5958/2231-5691.2019.00003.0

ABSTRACT:
The objective of the study was to prepare and evaluate immediate release tablet of efavirenz by using micellar solubilization technique to improve solubility and dissolution rate of poorly water soluble drug efavirenz. The tablets were prepared by wet granulation method using sodium lauryl sulphate as surfactant and crosscarmellose sodium and crospovidone as a superdisintegrants. Compatibility study was carried out by using FTIR and DSC found there was no drug – excipient interaction. F1-F9 batches were prepared and F9 batch showed good pre and post compression results, F9 batch showed disintegration time 1:34 min. and 98.99% drug release within 30 min. Also F9 batch was compared with marketed formulation showed better release of drug.
KEYWORDS:
Efavirenz, Immediate release tablet, SLS, Crosscarmellose sodium, Crospovidone
Cite:
Snehal B. Kulkarni, M. M. Bari, S. D. Barhate, Ashutosh Tripath. Formulation and Evaluation of Immediate Release Tablet of Efavirenz by Micellar Solubilization Technique. Asian J. Pharm. Res. 2019; 9(1): 12-18.
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