Volume No. :   8

Issue No. :  4

Year :  2018

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Calanolide A New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI): A Review



Address:   Mr. Mayur S. Jain*, Dr. Shashikant D. Barhate, Mr. Bhushan P. Gayakwad
Shree Sureshadada Jain Institutes of Pharmaceutical Education and Research, Jammer, Maharashtra (India).
*Corresponding Author
DOI No: 10.5958/2231-5691.2018.00041.2

ABSTRACT:
Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo. Calanolide A is a compound isolated from the latex of the tree, Calophyllum lanigerum (var. austrocoriaceum), that grows in the rain forest of the Malaysian state of Sarawak on the island of Borneo.
KEYWORDS:
Calanolide A, Anti-HIV activity, Reverse transcriptase inhibitor.
Cite:
Mayur S. Jain, Shashikant D. Barhate, Bhushan P. Gayakwad. Calanolide A New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI): A Review. Asian J. Pharm. Res. 2018; 8(4): 241-242.
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