Volume No. :   8

Issue No. :  4

Year :  2018

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Antimitotic Activity of Fruits of Momordica dioica by using Allium cepa Root Tip Assay



Address:   N. S. Patil*, K. B. Patil, M. R. Patil, R. A. Ahirrao
Department of Pharmaceutical Analysis, P. S. G. V. P. M’s College of Pharmacy, Shahada-425409, Dist- Nandurbar. (M.S) India.
*Corresponding Author
DOI No: 10.5958/2231-5691.2018.00037.0

ABSTRACT:
Objective: Cancer is a dreadful disease and combating this disease is of great importance to public health. Phytochemical examination has been making rapid progress and herbal products are becoming popular as sources of plausible anticancer compounds. In the present study we have utilized the Allium cepa root tip meristem model to evaluate antimitotic activities of fruits of Momordica dioica commonly known as kakrol, spiny gourd or teasle gourd belongs to family cucurbitaceae. Methods: Preliminary antimitotic screening was done using Allium cepa root tip assay. The herbal powder obtained from plant part-dry fruits of Momordica dioica were extracted with aqueous solvents by maceration methods. The antimitotic activity was analysed using Allium cepa root and methotrexate was used as a standard drugs. Result and discussion: In Allium assay, aqueous extract of fruits of Momordica dioica (10 mg/ml) and methotrexate showed significant concentration dependant inhibitory influence against the dividing cells of Allium roots and decreased root growth and mitotic index as compared to control distilled water. The results indicated the cytotoxic potential of extract due to antimitotic effects. The effect may be attributed to the presence of flavonoids, alkaloids and phenolic compounds in Momordica dioica fruits extract. Conclusion: The present work revealed that fruits of Momordica dioica contain some important chemical constituents extracted using aqueous as solvent that can be used further in the management of cancer treatment.
KEYWORDS:
Allium cepa, Momordica dioica, cucurbitaceae, maceration, flavanoids, alkaloids and phenolic compounds.
Cite:
N. S. Patil, K. B. Patil, M. R. Patil, R. A. Ahirrao. Antimitotic Activity of Fruits of Momordica dioica by using Allium cepa Root Tip Assay. Asian J. Pharm. Res. 2018; 8(4): 221-224.
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