Volume No. :   8

Issue No. :  3

Year :  2018

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Preliminary Phytochemical Investigation and In Vitro Anti Bacterial Studies of Polycarpaea aurea Wight and Arn (Caryophyllaceae) Emulgel.



Address:   Jamal Basha D*1, Srinivas Murthy BR2, Prakash P2, Anuradha KC2
1Department of Pharmacognosy, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati, Andhra Pradesh, India-517503.
2Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati, Andhra Pradesh, India-517503.
*Corresponding Author
DOI No: 10.5958/2231-5691.2018.00027.8

ABSTRACT:
Herbal medicine has become item of global importance both medicinal and economical. Natural medicine from a plant origin is still used as exceptional therapeutic agents especially for treating bacterial, fungal, viral, protozoal and helementic infections. Polycarpaea aurea Weight and Arn perennial herb belongs to Caryophyllaceae. It is commonly known as Rathirajuma. The whole herb traditionally used for the treating microbial infections, diabetes and dysentery effectively. In the present study an attempt was made to formulate emulgel containing methanolic plant extract. The authenticated plant powder drug subjected to successive solvent extraction for the screening of active phytochemical compounds. Different emulgels were prepared by using constant amount of gelling agent and by varying penetration enhancers i.e lavender oil (F1), eucalyptus oil (F2), orange oil (F3) and mentha oil (F4). Emulgels were further subjected to evaluation of physical properties like colour, pH, consistency, spreadability and viscosity. The emulgels were evaluated for antibacterial efficiency by agar diffusion method against gram +ve and gram –ve strains. All formulations were found to be optimum in terms of pH, colour, drug content, viscosity and extrudability. Maximum release was shown by F3 (96%). The formulation F3 showed greatest zone of inhibition and it showed potential antibacterial activity against various gram +ve and gram –ve strains than the remaining formulations and standard ofloxicin drug.
KEYWORDS:
Polycarpaea aurea, emulgel, penetrant enhancers, evaluation, successive solvent extraction.
Cite:
Jamal Basha D, Srinivas Murthy BR, Prakash P, Anuradha KC. Preliminary Phytochemical Investigation and In Vitro Anti Bacterial Studies of Polycarpaea aurea Wight and Arn (Caryophyllaceae) Emulgel. Asian J. Pharm. Res. 2018; 8(3): 151-157.
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