Volume No. :   8

Issue No. :  3

Year :  2018

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Thalassemia: A Review



Address:   Rahamat Unissa1*, Bayyaram Monica1, Sowmya Konakanchi1, Rahul Darak2, Sandagalla Lipi Keerthana1, Saranya Arun Kumar1
1Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad, Osmania University, Telangana, India.
2Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhulapally, Secunderabad, J.N.T University, Telangana, India.
*Corresponding Author
DOI No: 10.5958/2231-5691.2018.00034.5

ABSTRACT:
Thalassemia is a group of inherited diseases of the blood that affect a person's ability to produce hemoglobin, resulting in anemia. Around 100,000 cases of thalassemia’sare found every year in the new born babies.Chances of occurrence of these cases are more among people of Italian, Greek, Middle Eastern, Southern Asian and African Ancestry. Thereare two main types of thalassemia are called "alpha" and "beta," depending on which part of an oxygen-carrying protein in the red blood cells is lacking. Both types of thalassemia are inherited in the same manner. The disease is passed to children by parents who carry the mutated thalassemia gene. A child who inherits one mutated gene is a carrier, which is sometimes called "thalassemia trait." Most carriers lead completely normal, healthy lives. Diagnosis is usually done by hematologic tests, hemoglobin electrophoresis, and DNA analysis. Individuals with severe thalassemia require blood transfusion, drug therapy i.e. deferoxamine, deferasirox, deferiprone, and bone marrow transplant. Bone Marrow Transplant (BMT) is still remains the only definitive cure available for patients with Thalassemia.The present paper discuss about the various types of Thalassemia’s,their etiology, pathophysiology, clinical features, complication, prevention and treatment.
KEYWORDS:
Thalassemia’s, Bone Marrow Transplant, hemoglobin, inherited disease
Cite:
Rahamat Unissa, Bayyaram Monica, Sowmya Konakanchi, Rahul Darak, Sandagalla Lipi Keerthana, Saranya Arun Kumar. Thalassemia: A Review . Asian J. Pharm. Res. 2018; 8(3): 195-202.
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