Volume No. :   8

Issue No. :  3

Year :  2018

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Genetic Insights of Cholesterol and Atherosclerosis: Complex Biology



Address:   Kishan L. Jadhav*1, Priyanka R. Kapare1, Divya V. Khairmode1, Chaitali H. Keskar1, Farida Shaikh1, Shradda Sawant1, Akash S. Mali1,2
1Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara [MS] India.
2Vytautas Magnus University, Kaunas, Lithuania
*Corresponding Author
DOI No: 10.5958/2231-5691.2018.00031.X

ABSTRACT:
Atherosclerosis is multifaceted arterial disease involving collaboration of chromosomal and conservational factors, around seven million Americans are experiencing a heart attack during their lifetime. Many biomolecules play different roles in atherosclerosis such as 5-LO enzyme which play vital role in synthesis of leukotrienes inflammatory intermediates and proteins. Previous studies show that individuals suffering from coronary artery disease more commonly have C. pneumonia antibody than inhabitant’s controls. In recent years the genes and genetic polymorphism which are associated with atherosclerosis had been identified. Phospholipid transfer protein will subsequently decrease the HDL mass and cholesterol efflux capacity due to its overexpression and deletation. Our aim of this review is to demonstrate complex biology of atherosclerosis and effect of cholesterol in cardiovascular diseases.
KEYWORDS:
Atherosclerosis, Cholesterol, Apo-E gene, Reverse cholesterol transport Cardiovascular diseases.
Cite:
Kishan L. Jadhav, Priyanka R. Kapare, Divya V. Khairmode, Chaitali H. Keskar1, Farida Shaikh, Shradda Sawant, Akash S. Mali. Genetic Insights of Cholesterol and Atherosclerosis: Complex Biology. Asian J. Pharm. Res. 2018; 8(3): 175-184.
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