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Asian Journal of Pharmaceutical Research
ISSN: 2231-5691(Online), 2231-5683(Print)
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Evaluation of anti-inflammatory activity of Hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilisation.
Uma Sankar Gorla
. M. Savithri
G.S.N. Koteswara Rao
. Y. Niharika
. P. Devi Sree Sathya
. V. Harika
Mr. Uma Sankar Gorla*, Dr. M. Savithri, Dr. G.S.N. Koteswara Rao, Ms. Y. Niharika, Ms. P. Devi Sree Sathya, Ms. V. Harika
Viswanadha Institute of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh, India.
Objectives: To evaluate invitro anti-inflammatory activity of hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilisation. Methods: Hydroalcoholic extract was prepared by soxhlet extraction and thereafter subjected for membrane stabilisation assay to evaluate anti-inflammatory property. 10% human red blood cell suspension was subjected to hyptonicity induced hemolysis and inhibition of membrane damage by the extract was compared to the standard drug diclofenac sodium. Results: Hypotonicity induced HRBC membrane lysis was inhibited by hydroalcoholic extract of Ananas cosmosus fruit peel in a concentration dependent manner. Hydroalcoholic extract showed 72.86% protection of HRBC membrane at 250µg/ml and showed significant membrane stabilisation compared with standard drug diclofenac sodium at the same concentrations. Conclusion: Ananas cosmosus fruit peel extract showed appreciable HRBC membrane stabilisation and may have potential anti-inflammatory property. Further analysis is to be carried out to isolate active chemical constituent responsible for anti-inflammatory activity and its mechanism involved.
Ananas cosmosus, HRBC membrane, anti-inflammatory, hemolysis, soxhlet.
Uma Sankar Gorla,. M. Savithri, G.S.N. Koteswara Rao,. Y. Niharika, . P. Devi Sree Sathya, . V. Harika. Evaluation of anti-inflammatory activity of Hydroalcoholic extract of Ananas cosmosus fruit peel by HRBC membrane stabilisation.Asian J. Pharm. Res. 2018; 8(1):33-35.
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