Volume No. :   7

Issue No. :  4

Year :  2017

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Synthesis and Evaluation of Antidiabetic Activity of Few 5-(4-(5-Substitutedphenyl)-1,3,4-Oxadiazlole-2-Yl) Methoxy)Benzylidene) Thiazolidine 2,4-Dione Derivatives



Address:   Roshani Bhalerao*, Dinesh Rishipathak, Pavan Udavant, Sanjay Kshirsagar
MET’S Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik-422003, Savitribai Phule Pune University, India
*Corresponding Author
DOI No: 10.5958/2231-5691.2017.00041.7

ABSTRACT:
The aim of study was to synthesize a new series of Thiazolidinedione. Thiazolidinedione or glitziness forms a significant class of drug which exhibit biological activities ranging from antidiabetic, antiinflamatory, antibacterial, antifungal, antiviral, and anti-cancer. In the present study reported a systematic synthesis of thiazolidinedione. A new series of 2,4-thiazolidinedione based derivative have been synthesize by condensation of. The structure of these compounds were establish by IR and 1H NMR. These new compound (C1-C4) were evaluated for their antidiabetic activity on albino rat. Most of compound shows significant antidiabetic activity when compare with standard drug metformin.
KEYWORDS:
Diabetic Mellitus, Thiazolidinedione, antidiabetic activity.
Cite:
Roshani Bhalerao*, Dinesh Rishipathak, Pavan Udavant, Sanjay Kshirsagar. Synthesis and Evaluation of Antidiabetic Activity of Few 5-(4-(5-Substitutedphenyl)-1,3,4-Oxadiazlole-2-Yl) Methoxy)Benzylidene) Thiazolidine 2,4-Dione Derivatives. Asian J. Pharm. Res. 2017; 7(4): 261-264.
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