Volume No. :   7

Issue No. :  2

Year :  2017

ISSN Print :  2231-5683

ISSN Online :  2231-5691


Registration

Allready Registrered
Click to Login

Synthesis of novel 3-[(dialkyl/aryl amino) methyl]-2-substituted-4(3H)-Quinazolinones and evaluation of their Anti-inflammatory activity



Address:   Ganesh Akula1*, Rangu Nirmala2, CH. Shanthipriya2, S. Rohini Reddy2, Dr. A. Jaswanth2
1Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312
2Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312
*Corresponding Author
DOI No: 10.5958/2231-5691.2017.00010.7

ABSTRACT:
Literature survey reveals that in recent years several Quinazolinone derivatives have been synthesized and reported to possess varied biological and pharmacological properties. They are found to be useful as antibacterial, analgesic, anti-inflammatory, antifungal, anticonvulsant and anticancer agents. A new series of 3-[(di alkyl amino) methyl]-2-substituted-4(3H)-Quinazolinones were synthesized by the reaction of a mixture of 2-substituted-4(3H)-Quinazolinone, formaldehyde and dialkyl or diaryl amine by mannich reaction. The chemical structures of the synthesized compounds were confirmed by IR, mass spectral and C, H, N analysis techniques. The synthesized compounds were screened for anti-inflammatory activity by the carrageenan induced rat hind paw edema method. The synthesized compounds were significantly showed their anti-inflammatory activity that of standard.
KEYWORDS:
Quinazolinone, Isomer, Analgesic, Anti-inflammatory, Carrageenan.
Cite:
Ganesh Akula, Rangu Nirmala, CH. Shanthipriya, S. Rohini Reddy, A. Jaswanth. Synthesis of novel 3-[(dialkyl/aryl amino) methyl]-2-substituted-4(3H)-Quinazolinones and evaluation of their Anti-inflammatory activity. Asian J. Pharm. Res. 2017; 7(2): 60-62.
[View HTML]      [View PDF]



Visitor's No. :   122306