Volume No. :   7

Issue No. :  1

Year :  2017

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Protective effect of Pueraria tuberosa Linn. in arsenic induced nephrotoxicity in rats.



Address:   V. Uma Rani1*, Dr. M. Sudhakar1, Dr. A. Ramesh2
1Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad, Affiliated to Osmania University, Telangana, India.
2Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Telangana, India.
*Corresponding Author
DOI No: 10.5958/2231-5691.2017.00003.X

ABSTRACT:
Pueraria tuberose Linn. is an inexpensive and efficient source to provide all the required nutrients and medicinal benefits for a healthy and rejuvenating body. The present investigation has been undertaken to evaluate the role of Pueraria tuberosa Linn. in modifying the sodium arsenate induced biochemical alterations in albino rats. Administration of sodium arsenate in rats induces oxidative stress, which leads to the generation of free radicals in the body. These free radicals interact with tissue leading to tissue damage i.e, kidney damage. Animals were divided into 6 groups, Group I (control group) rats were treated with normal saline (1mg/kg), Group II ( Positive Control) rats were treated with sodium arsenate (1mg/kg).Group III rats were treated with sodium arsenate (1mg/kg) and Vitamin E (100 mg/kg).Group IV rats were treated with sodium arsenate (1mg/kg) and Pueraria tuberosa linn. extract (50 mg/kg), Group V rats were treated with sodium arsenate (1mg/kg) and Pueraria tuberosa linn. extract (100 mg/kg) , Group VI rats were treated with sodium arsenate (1mg/kg) and hydroalcoholic extract of Pueraria tuberose linn (200mg/kg). After 21 days treatment, blood samples were collected and analyzed for the serum parameters viz BUN test, serum calcium test, serum iron test, Acid phosphatase test, Creatinine test. Antioxidant parameters like Malondialdehyde, catalase, Reduced glutathione and glutathione reductase were estimated. The kidney is removed and sectioned for histopathological examination. The hydroalcoholic extract of Pueraria tuberosa linn (tuber) inhibits the oxidative stress hypothesis mechanism. It was concluded that the extract of Pueraria tuberose linn (tuber) exerts nephroprotective activity could be attributed by presence of natural antioxidants, free radical scavenging.
KEYWORDS:
Sodium arsenate, Nephrotoxicity, Blood toxicity, oxidative stress, Kidney ctamases
Cite:
V. Uma Rani, M. Sudhakar, A. Ramesh. Protective effect of Pueraria tuberosa Linn. in arsenic induced nephrotoxicity in rats. Asian J. Pharm. Res. 2017; 7(1): 15-20.
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