Volume No. :   6

Issue No. :  3

Year :  2016

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Antidepressant, Analgesic Activity and SAR Studies of Substituted Benzimidazoles



Address:   Nadeem Siddiqui1*, Md Shamsher Alam1,2, Meeta Sahu1, M. Shahar Yar1 , Ozair Alam1, Mohammad Jamshed Ahmad Siddiqui3
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India.
2Department of Pharmaceutical Chemistry, College of Pharmacy, P.O. Box no. 114, Jazan University, Jazan, KSA.
3Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University, Malaysia, Kuantan 25200.
*Corresponding Author
DOI No:

ABSTRACT:
Purpose. Benzimidazole class of compound is found to have diverse biological properties. From the literature study, it is observed that depression is a severe mental disease affecting a huge population and pain is affecting about 20% of world population. In continuation of our previous research work, we selected benzimidazole pharmacophore to further explore its pharmacological activities. Methods. Forced swim test and Thermal stimulus test were used to assess the antidepressant and analgesic activity of synthesized benzimidazole analogs. Results. The antidepressant activity results showed that compound 3j was found most potent having Mean ± SEM value 21.6 ± 0.8 for treated group. Furthermore, in the analgesic test, 3b, 3j, and 3o showed Mean ± SEM values; 1.8 ± 0.10, 2.3 ± 0.10 and 2.2 ± 0.10, respectively. The study results suggested that these compounds could be explored further for the development of better antidepressant and analgesic agents. Conclusion. From the present study, it may be concluded that these active benzimidazole derivatives have been found to possess potential antidepressant and analgesic activity.
KEYWORDS:
Benzimidazole, Antidepressant, Analgesic, Structure activity relationship, Log P.
Cite:
Nadeem Siddiqui, Md Shamsher Alam, Meeta Sahu, M. Shahar Yar, Ozair Alam, Mohammad Jamshed Ahmad Siddiqui. Antidepressant, Analgesic Activity and SAR Studies of Substituted Benzimidazoles. Asian J. Pharm. Res. 2016; 6(3): 170-174.
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