Volume No. :   6

Issue No. :  1

Year :  2016

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Synthesis and evaluation of novel Flavonoid derivatives for Antibacterial activity



Address:   Sushil D. Patil1*, Masood Ahemed Hafizur H1, Aher Priti R.1, Pravin B. Shelke1, Samruddhi Yardi2
1Department of Pharmaceutical Chemistry, MET Institute of Pharmacy, Adagaon, Nashik, S.P. Pune University, M.S., India.
2T.Y.B. Pharm, Department of Pharmaceutical Chemistry, MET Institute of Pharmacy, Adagaon, Nashik, S.P. Pune University, M.S., India.
*Corresponding Author
DOI No: 10.5958/2231-5691.2016.00005.8

ABSTRACT:
Flavones are the derivatives of flavonoids, possessing the wider range of biological actions. A series of flavonoid derivatives with the help of substituted benzaldehyde were synthesized and evaluated for antibacterial activity by cup-plate agar diffusion method. Out of six compounds 1-(2, 4- dihydroxyphenyl)-3-(4-(dimethyl amino) phenyl) prop-2ene-1one.(MCR-001) and 2-(4-(Di-methylamino) phenyl)-7-hydroxy-4-H-chromen-4-one. (MCR-002), 2-hydroxy-2-(4-(methyl (4-nitrostyryl) amino) phenyl)-4-oxochroman-7-yl benzoate. (MCR-004) and 2-(4-dimethyl amino) phenyl)-4-oxo-4H-chromen-7-yl benzoate. (MCR-005) 2-(4-dimethyl amino) phenyl)-2-hydroxy 4-oxochroman-6-yl benzoate (MCR-005) have shown promising antibacterial activity also 7-hydroxy-2-(4-methyl (4-nitrostyryl) amino) phenyl)-4-H-chromen-4-one (MCR-003) ) and 2-(4-(4-chlorobenzyl) methyl) amino) phenyl)-2, 6-dihydroxychroman-4-one. (MCR-006) shown moderate antibacterial activity. This work has revealed the scope and potential of flavonoids for future exploration to synthesize substituted flavonoids and chalcone derivatives by the use of different substituted benzaldehyde.
KEYWORDS:
Flavonoid, agar diffusion method, antibacterial activity.
Cite:
Sushil D. Patil, Masood Ahemed Hafizur H, Aher Priti R., Pravin B. Shelke, Samruddhi Yardi. Synthesis and evaluation of novel Flavonoid derivatives for Antibacterial activity. Asian J. Pharm. Res. 6 (1): January -March, 2016; Page 27-30.
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