Volume No. :   6

Issue No. :  1

Year :  2016

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Simultaneous Determination of Paracetamol and Domperidone in Pharmaceutical Dosage Form by First Order Derivative UV Spectrophotometry



Address:   Audumbar Mali1*, Sujata Kolekar2, Jeeja Panachery3, Ashpak Tamboli4
1Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
2Department of Quality Assurance, Shri D.D. Vispute college of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Mumbai, Maharashtra, India.
3Department of Pharmacognosy and Phytochemistry, Shri D.D. Vispute college of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Mumbai, Maharashtra, India.
4Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
*Corresponding Author
DOI No: 10.5958/2231-5691.2016.00004.6

ABSTRACT:
Derivative spectrophotometry offers a useful approach for the analysis of drugs in multi-component formulation. In this study a first order derivative spectrophotometric method is applied for the simultaneous determination of Paracetamol and Domperidone in Tablet dosage form. The measurements were carried out at wavelengths of 262 and 297 nm for Paracetamol and Domperidone respectively. The method was found to be linear (r²=0.999) in the range of 5-25 µg/ml for Paracetamol in the presence of 20µg/ml of Domperidone at 262 nm. The linear correlation (r²=0.999) was obtained in the range of 5-25µg/ml for Domperidone in the presence of 20µg/ml of Paracetamol at 297 nm. The method was successfully used for simultaneous determination of Paracetamol and Domperidone in tablet dosage form without any interference from excipients and prior separation.
KEYWORDS:
Paracetamol, Domperidone, UV visible spectrophotometry, Method Validation, First order derivative method.
Cite:
Audumbar Mali, Sujata Kolekar, Jeeja Panachery, Ashpak Tamboli.Simultaneous Determination of Paracetamol and Domperidone in Pharmaceutical Dosage Form by First Order Derivative UV Spectrophotometry. Asian J. Pharm. Res. 6(1): January -March, 2016; Page 22-26.
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