Volume No. :   5

Issue No. :  3

Year :  2015

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Pharmacological Evaluation of Trichilia connaroides Bark for Analgesic and Anti-inflammatory activity in Experimental Animal Models



Address:   Muhammed Shakkeel K.V1*, Anjan Kumar1, Veeresh Babu. D1, Narayana Swamy V.B2
1Department of Pharmacology, Karavali College of Pharmacy, Mangalore.
2Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore
*Corresponding Author
DOI No: 10.5958/2231-5691.2015.00021.0

ABSTRACT:
The present study was designed to evaluate the analgesic and anti-inflammatory activity of “Trichilia connaroides” bark using different animal models. Analgesic activity was evaluated by using various two animal models namely, Writing Test using acetic acid in mice and Hot Plate Method. The degree of analgesic activity was determined by the number of wriths was recorded for each animal in Writing Test using acetic acid in mice model and the delay in reaction time for of each animal when place in hot plate maintained at 55±0.10c is recorded in Hot Plate Method. Anti-inflammatory activity was evaluated using Formalin induced paw edema model, Croton oil ear edema in rats. Trichilia connaroides bark ethanolic extracts produced significant analgesic activity in both Hot plate and acetic acid induced writhing models in mice. In hot plate method percentage increase in reaction time was determined where as in acetic acid induced writhing model percentage decrease in writhings was determined. Evaluation of anti inflammatory activity was done by Formalin induced paw edema model, Croton oil ear edema model. In Formalin induced paw edema model mean change in paw volume and percentage protection were calculated. In croton oil ear edema model the difference between untreated ear and treated ear were determined which indicated degree of inflammatory edema. The study revealed that the “Trichilia connaroides”bark possess a significant analgesic and anti-inflammatory activity.
KEYWORDS:
“Trichilia connaroides” bark, Writing Test using acetic acid, Hot Plate Method, Formalin induced paw edema model, Croton oil ear edema in rats.
Cite:
Muhammed Shakkeel K.V, Anjan Kumar, Veeresh Babu. D, Narayana Swamy V.B. Pharmacological Evaluation of Trichilia connaroides Bark for Analgesic and Anti-inflammatory activity in Experimental Animal Models. Asian J. Pharm. Res. 5(3): July- Sept., 2015; Page 138-144.
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