Volume No. :   5

Issue No. :  2

Year :  2015

ISSN Print :  2231-5683

ISSN Online :  2231-5691


Registration

Allready Registrered
Click to Login

Development of classical least square method for the determination of Candesartan and Hydrochlorthiazide in tablet dosage form



Address:   S. J. Daharwal*, Veena D. Singh
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010 Chhattisgarh, India.
*Corresponding Author
DOI No: 10.5958/2231-5691.2015.00013.1

ABSTRACT:
A new simple spectrophotometric method was developed for the determination of binary mixtures of Candesartan cilexetil (CAND) and Hydrochalorothiazide (HCTZ), without prior separation. The method is based on the multi-wavelength technique i.e. classical least square (CLS) method. The tablet is determined by the multi-wavelength technique (CLS), at the wavelengths range of 215-225 nm over the concentration ranges of 2.5–50 and 1–30 µg/mL with mean recovery more than 98% for both drugs CAND and HCTZ, respectively .The proposed spectrophotometric method was validated and successfully applied for the assay of drug combination in several laboratory-prepared mixtures and commercial tablets.
KEYWORDS:
Spectrophotometric analysis; Classical least square method; Candesartan; Hydrochlorothiazide.
Cite:
S. J. Daharwal, Veena D. Singh. Development of classical least square method for the determination of Candesartan and Hydrochlorthiazide in tablet dosage form. Asian J. Pharm. Res. 5(2): April-June 2015; Page 90-95.
[View HTML]      [View PDF]



Visitor's No. :   89260