Volume No. :   4

Issue No. :  4

Year :  2014

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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QSAR Study and Synthesis of some new 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives as Anti-microbial and Anti-inflammatory Agents



Address:   Nachiket S. Dighe1*, Pankaj Shinde1, Harshali Anap1, Sanjay Bhawar2 and Deepak S. Musmade3
1Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, India-413736.
2Department of Pharmacology, Pravara Rural College of Pharmacy, Loni, MS, India-413736.
3Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, India
*Corresponding Author
DOI No:

ABSTRACT:
The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial and Anti-inflammatory at the concentration of 200 µcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E.coli, S. aureus, A.niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Ciprofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Zaltoprofen as a standard.
KEYWORDS:
Anti-inflammatory, Antimicrobial and Oxadiazole.
Cite:
Nachiket S. Dighe, Pankaj Shinde, Harshali Anap, Sanjay Bhawar, Deepak S. Musmade. QSAR Study and Synthesis of some new 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives as Anti-microbial and Anti-inflammatory Agents. Asian J. Pharm. Res. 4(4): Oct.-Dec.2014; Page 174-179.
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