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Asian Journal of Pharmaceutical Research
ISSN: 2231-5691(Online), 2231-5683(Print)
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A Review on Genotoxicity
Ahamed Noor Mansoori
Rupesh K. Gautam
Prafulla C. Tiwari
Ahamed Noor Mansoori, Rupesh K. Gautam*, Prafulla C. Tiwari
Department of Pharmacology, Jaipur College of Pharmacy, ISI-15, RIICO Institutional Area, Tonk Road, Sitapura, Jaipur, India-302022
Genotoxicity studies used to investigate the potency of a compound to interact with the constitution of genetic. An alteration of the genetic code via gene mutations (point mutations) or DNA strand breaks may lead to fundamental changes DNA damage in a somatic cell may result in a somatic mutation, which may lead to malignant transformation (cancer). A genotoxin is an agent or chemical that can cause DNA or chromosomal damage. Such damage in a germ cell has the potential to cause a heritable altered trait (germline mutation). Many chemical carcinogens/ mutagens undergo metabolic activation to reactive species that bind covalently to DNA, and the DNA adducts thus formed can be detected in cells and in human tissues by a variety of sensitive techniques. The present study was aimed to provide information regarding genotoxicity.
Genotoxin, Chromosomal damage, Carcinogen, Gene mutations.
Ahamed Noor Mansoori, Rupesh K. Gautam, Prafulla C. Tiwari. A Review on Genotoxicity. Asian J. Pharm. Res. 4(3): July-Sept. 2014; Page 162-165.
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