Volume No. :   4

Issue No. :  3

Year :  2014

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Diphendramine Hydrochloride Oral Dispersible Tablets: Preparation and Evaluation



Address:   K. Vijaya Sri*, R. Harish Kumar Reddy and R. Mahesh
Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Andhra Pradesh, India.
*Corresponding Author
DOI No:

ABSTRACT:
The purpose of this research was to make an attempt to develop mouth dissolving tablets of diphenhydramine hydrochloride. Mouth dissolving tablet offers a solution for pediatrics, adolescents and geriatrics patients those have difficulty in swallowing tablets/capsules, resulting in improved patient compliance. Diphenhydramine is used as anti emetic, anti tussive for dermatosis and pertusis and for hypersensitivity reactions. The aim is to formulate different formulations of mouth dissolving tablets of diphenhydramine hydrochloride using different superdisintegrants like crospovidone and croscarmellose sodium and subliming agent menthol, by direct compression and sublimation method. Precompression parameters were characterized for flow properties and prepared tablets were evaluated for hardness, thickness, friability, weight variation, wetting time, water absorption ratio, drug content, disintegration time and dissolution studies. Invitro dissolution studies show that release in tablets with a combination of superdisintegrant and subliming agent was good. Among all the formulations, F9 (10% crospovidone and menthol)showed maximum drug release of 99.76% in 12min.Hence it is evident from this study that mouth dissolving tablets could be a promising delivery system for diphenhydramine hydrochloride with good mouth feel and improved drug bioavailability with better patient compliance.
KEYWORDS:
Mouth dissolving tablet, super disintegrants, subliming agent, diphenhydramine hydrochloride, direct compression, sublimation.
Cite:
K. Vijaya Sri, R. Harish Kumar Reddy , R. Mahesh. Diphendramine Hydrochloride Oral Dispersible Tablets: Preparation and Evaluation. Asian J. Pharm. Res. 4(3): July-Sept. 2014; Page 123-128.
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