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Asian Journal of Pharmaceutical Research
ISSN: 2231-5691(Online), 2231-5683(Print)
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Designing and Optimization of Modified Dissolution Apparatus for Evaluation of Medicated Chewing Gum of Ambroxol HCl
S. J. Daharwal
Veena Devi Thakur
Bhanu Pratap Sahu
Dr. S. J. Daharwal*, Veena Devi Thakur, Shikha Shrivastava and Bhanu Pratap Sahu
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) India
Chewing gums cannot be assayed unlike tablet by the conventional method that is by crushing the tablet and weighing an accurate amount of medicament and estimating its content. For estimation of the drug content and the study of drug release process from chewing gums a new apparatus (Erweka’s DRT 6 Chewing apparatus) has been designed which mimics the natural chewing actions. The drug content was found to be in the range of 95.20 to 99.21% or 28.56 to 29.76 mg. highest drug content and the lowest drug content were found with formulation F5 and formulation F7 of Ambroxol hydrochloride respectively. The present study deals with in-vitro drug release of Medicated chewing gumFormulation F5showed highest drug release of 98.74% and formulation F7 showed lowest drug release of 85.74% respectively at the end of 30 minutes.
Erweka DRT 6 chewing apparatus, medicated chewing gum, Ambroxol HCl.
S. J. Daharwal, Veena Devi Thakur, Shikha Shrivastava , Bhanu Pratap Sahu. Designing and Optimization of Modified Dissolution Apparatus for Evaluation of Medicated Chewing Gum of Ambroxol HCl. Asian J. Pharm. Res. 3(3): July-Sept. 2013; Page 141-143.
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