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Asian Journal of Pharmaceutical Research
ISSN: 2231-5691(Online), 2231-5683(Print)
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Solid State Compatibility Study of Rice Bran Wax with Nifedipine for its Use in Pharmaceutical Products
Avish D. Maru
Prashant V. Bodhe
Rajendra K. Surawase
Avish D. Maru*, Prashant V. Bodhe, Rajendra K. Surawase
Loknete Dr. J. D. Pawar College of Pharmacy, A/P-Manur, Tal- Kalwan, Dist- Nasik (M.S.)
Rice bran wax is a natural vegetable wax and is a value added by-product of Rice bran oil refineries. It is hard nontacky wax and contains higher fatty alcohols and esters which make it comparable to Carnauba wax. In the present work, studies are carried out on Rice bran wax for various physico-chemical properties like solubility, melting point, specific gravity, moisture content, saponification value, acid value, ester value, hydroxyl value, unsaponifiable matter, Iodine number etc. Moreover the solid state compatibility studies was carried out by using mixture of Nifedipine and RBW in the 1:1 ratio at 60° c for 15 days and observed for its physical changes i. e. discoloration, liquefaction, gas formation etc and chemical changes i.e. interaction in between Nifedipine and RBW. It was carried out by using Differential Scanning Colorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FT-IR). The result shows that there are no physical and chemical changes; therefore RBW can be used in formulations of Nifedipine.
Rice bran Wax, Solid state compatibility study, Nifedipine.
Avish D. Maru, Prashant V. Bodhe, Rajendra K. Surawase. Solid State Compatibility Study of Rice Bran Wax with Nifedipine for its Use in Pharmaceutical Products. Asian J. Pharm. Res. 2(2): April-June 2012; Page 83-85.
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