Volume No. :   2

Issue No. :  2

Year :  2012

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Synthesis, Characterization and Its Biological Evaluation of Some Novel 4-Thiazolidinone and 2-Azetidinone Derivatives



Address:   P. Jaya Preethi*, K. Bindu Sree, K. Pavan Kumar, R. Rajavelu and T. Sivakumar
Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode, Tamil Nadu, India 638052
*Corresponding Author
DOI No:

ABSTRACT:
In the present study, a series of 4-thiazolidinones and 2-azetidinone derivatives were synthesized by refluxing Schiff bases with different aromatic aldehydes. Schiff bases were synthesized by reaction of nicotinamide with hydrazine hydrate. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy and elemental analysis. These compounds were screened for anti-tubercular, anti-convulsant anti-bacterial and anti-fungal activities. Anti-Tubercular activity mycobacterium tuberculosis and MIC level of the compounds was less than 6.25 µg/ml. Compound IIIa, IIId, IVa and IVd exhibited good Anti-convulsant activity. Compound IIIa, IIIc IIId, IVa, IVc and IVd exhibited good antibacterial activity on Gram-positive and Gram-negative microorganisms. All the synthesized compounds exhibited good Antifungal activity.
KEYWORDS:
Schiff base, nicotinamide, hydrazine hydrate, anti-bacterial, anti-fungal, anti-tubercular, anti-convulsant.
Cite:
P. Jaya Preethi, K. Bindu Sree, K. Pavan Kumar, R. Rajavelu , T. Sivakumar. Synthesis, Characterization and Its Biological Evaluation of Some Novel 4-Thiazolidinone and 2-Azetidinone Derivatives. Asian J. Pharm. Res. 2(2): April-June 2012; Page 63-70.
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