Volume No. :   2

Issue No. :  1

Year :  2012

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Secondary Metabolite screening, Bioactive compound extraction, and Disrupting Mitotic Activity of Wild Cabbage [Brassicaceae] towards Cancer Management.



Address:   A. Thenmozhi1, Dr. U.S Mahadeva Rao2*
1Assistant Professor, PG Department of Biochemistry, SRM Arts and Science College, Chennai-603203, India.
2Associate Professor, Department of Biochem., Faculty of Medicine and Health Science, Universiti Sultan Zainal Abidin, Malaysia.
*Corresponding Author
DOI No:

ABSTRACT:
Objective: The present study has been formulated with an objective to establish the preliminary phytochemical analysis and antimitotic activity of Brassica oleracea. Method: Brassica oleracea was collected, homogenized and extracted with different solvents. Antimitotic activity of Brassica oleracea was evaluated using the meristamatic cells from the root of Allium cepa. Experiments were carried out with incorporation of folic acid in the extract. Results: The preliminary study revealed the presence of flavonoids, steroids, alkaloids, saponins, polyphenols and glycosides. Folic acid inhibited the antimitotic activity of Brassica oleracea extract. The antimitotic activity obtained was compared with methotrexate-a referred anticancer drug. Discussion: The results obtained from the present study pinpoint that antimitotic activity of Brassica oleracea may be due to the presence of flavonoids, steroids, alkaloids, polyphenols and saponins. Conclusion: Hence Brassica oleracea is a promising source of phytochemicals which promote human health by strengthening the human immune system, inactivate cancer-causing substances, protect the heart and eyes from disease, boost enzyme activity to increase the benefits of the various protective enzymes, reduce bad cholesterol levels, and anti-aging.
KEYWORDS:
Antimitotic; Brassica oleracea; Allium cepa; Polyphenols; Saponins.
Cite:
A. Thenmozhi, U.S Mahadeva Rao. Secondary Metabolite screening, Bioactive compound extraction, and Disrupting Mitotic Activity of Wild Cabbage [Brassicaceae] towards Cancer Management. Asian J. Pharm. Res. 2(1): Jan.-Mar. 2012; Page 19-31.
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