Volume No. :   1

Issue No. :  4

Year :  2011

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Synthesis of Novel Thiazole Derivatives as Analgesic Agents

Address:   G. Saravanan*1, V. Alagarsamy2, C.R. Prakash2, P. Dinesh Kumar2 and T. Panneer Selvam2
1Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla-522 101, (A.P), India.
2Medicinal Chemistry Research Laboratory, M.N.R. College of Pharmacy, Sangareddy-502 294, (A.P), India.
*Corresponding Author

Thiazoles have a long history of having number of pharmacological activities such as anti-microbial, analgesic and anti-inflammatory activities. Pyrazoles shows promising anti-microbial, analgesic and anti-inflammatory activities. In the present study, novel thiazoles (8a – 8j) were synthesized by incorporation of pyrazole moiety at 2nd position of 2-hydrazinyl-N-(4-phenylthiazol-2-yl) acetamide (5) by treating with chalcones (7a-7j). The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, Mass spectral and Elemental analysis. All the spectral data were consistent with the assigned structure. The synthesized compounds were investigated for analgesic activity by tail immersion method in mice. All the synthesized compounds exhibited mild to good analgesic activities. Among the synthesized compounds, 2-(5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)-N-(4-phenylthiazol-2-yl)acetamide (8c) and 2-(5-(4-methylphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)-N-(4-phenylthiazol-2-yl)acetamide (8e) exhibited highest analgesic activity.
Thiazole, Pyrazole, Chalcone and Analgesic activity.
G. Saravanan, V. Alagarsamy, C.R. Prakash, P. Dinesh Kumar, T. Panneer Selvam. Synthesis of Novel Thiazole Derivatives as Analgesic Agents. Asian J. Res. Pharm. Sci. 1(4): Oct.-Dec. 2011; Page 134-138.
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