Volume No. :   1

Issue No. :  3

Year :  2011

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Development and Evaluation of Fast Disintegrating Tablets of Granisetron HCl with Natural and Synthetic Polymers



Address:   Prakash Goudanavar*, Doddayya Hiremath, Spandana D. and S. R. Reddy
Department of Pharmaceutics N.E.T Pharmacy College, Mantralayam Road, Raichur-584103, Karnataka, India
*Corresponding Author
DOI No:

ABSTRACT:
The present study was aimed at developing and evaluating fast disintegrating tablets of Granisetron HCl using natural superdisintegrants like Plantago ovata, gum karaya and agar and synthetic superdisintegrants like Indion 234, croscaramellose sodium and crospovidone in different concentration. Fast disintegrating tablets were prepared by direct compression method. Effect of superdisintegrants on wetting, disintegration and dissolution parameters were studied. Fast disintegrating tablets were characterized by Fourier Transform Infrared (FTIR) spectroscopy and Differential Scanning Calorimetry (DSC). Preformulation studies were found as per literature limits. Drug was compatible with superdisintegrants. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, in vitro dispersion time, wetting time, in vitro disintegration time, drug content and in vitro drug release. Results revealed that Formulation F2 containing 5% of Plantago ovata shown disintegration time of 17.10 sec and the drug release was up to 99.66% in 3 minutes. In vitro disintegration time decreases with increase in concentration of all superdisintegrants. Hence the present study revealed that this natural super disintegrants like Plantago ovata, gum karaya and agar showed better release than the most widely used synthetic superdisintegrants like Indion 234, crospovidone, Croscaramellose sodium in the formulations of FDTs.
KEYWORDS:
Fast disintegrating tablets, Granisetron HCl, Direct compression, Superdisintegrants.
Cite:
Prakash Goudanavar, Doddayya Hiremath, Spandana D. , S. R. Reddy. Development and Evaluation of Fast Disintegrating Tablets of Granisetron HCl with Natural and Synthetic Polymers. Asian J. Pharm. Res. 1(3): July-Sept. 2011; Page 72-77.
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