Volume No. :   1

Issue No. :  3

Year :  2011

ISSN Print :  2231-5683

ISSN Online :  2231-5691


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Development and Evaluation of Muco-Adhesive Ciprofloxacin Bi-Layer Tablet for Extended Drug Release



Address:   Asma Afroz1, Md. Asaduzzaman1, Md. Rezowanur Rahman2 and S.M. Ashraful Islam1*
1Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh
2Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh
*Corresponding Author
DOI No:

ABSTRACT:
The present study was undertaken to design and evaluate bilayer tablets of ciprofloxacin hydrochloride containing an immediate release layer and a mucoadhesive extended release layer. Tablets were prepared by direct compression method using Carbopol 934P, Hydroxylpropylmethylcellulose -15 cps (HPMC-15cps), Methocel K4M and Sodium Carboxymethylcellulose (Na-CMC) as mucoadhesive polymer. All the formulations showed uniform weight, thickness, crushing strength and content uniformity. Tablets were evaluated by mucoadhesive strength, ex-vivo residence time and in vitro drug release profile. Methocel K4M, HPLC-15 cps and Carbopol 934P based formulation (F-3, F-2 and F-1) showed maximum mucoadhesive strength (74.5 gm to 61.81 gm). Ex vivo residence time was 8.5 hr for F-3 and 6.75 hr for F-1. Time required for 100% drug release from F-1, F-2, F-3 and F-4 were 5 hr, 3 hr, 7 hr and 3 hr respectively. Release profile was compared with a commercial ciprofloxacin tablet. Higher sustained drug release was found in all formulations than the commercial product.
KEYWORDS:
Muco-adhesive, ciprofloxacin, bi layer tablet, extended drug release
Cite:
Asma Afroz, Md. Asaduzzaman, Md. Rezowanur Rahman, S.M. Ashraful Islam. Development and Evaluation of Muco-Adhesive Ciprofloxacin Bi-Layer Tablet for Extended Drug Release. Asian J. Pharm. Res. 1(3): July-Sept. 2011; Page 64-68.
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